Nano-Jewels in Biology. Gold and Platinum on Diamond Nanoparticles as Antioxidant Systems Against Cellular Oxidative Stress
| Autor: | José Raúl Herance, Hermenegildo García, Victor M. Victor, Cristina Menchón, Nadezda Apostolova, Roberto Martín, Mercedes Alvaro |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Antioxidant Biocompatibility Cell Survival medicine.medical_treatment Inorganic chemistry Intracellular Space General Physics and Astronomy chemistry.chemical_element Apoptosis chemical and pharmacologic phenomena medicine.disease_cause Platinum nanoparticles Antioxidants Catalysis chemistry.chemical_compound Materials Testing medicine Humans General Materials Science Cell Proliferation Platinum Hydroxyl Radical General Engineering Glutathione Oxidative Stress chemistry Nanoparticles Gold Particle size Diamond Oxidative stress HeLa Cells |
| Zdroj: | ACS Nano. 4:6957-6965 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/nn1019412 |
| Popis: | Diamond nanoparticles (DNPs) obtained by explosive detonation have become commercially available. These commercial DNPs can be treated under Fenton conditions (FeSO(4) and H(2)O(2) at acidic pH) to obtain purer DNP samples with a small average particle size (4 nm) and a large population of surface OH groups (HO-DNPs). These Fenton-treated HO-DNPs have been used as a support of gold and platinum nanoparticles (≤2 nm average size). The resulting materials (Au/HO-DNP and Pt/HO-DNP) exhibit a high antioxidant activity against reactive oxygen species induced in a hepatoma cell line. In addition to presenting good biocompatibility, Au/HO- and Pt/HO-DNP exhibit about a two-fold higher antioxidant activity than glutathione, one of the reference antioxidant systems. The most active material against cellular oxidative stress was Au/HO-DNP. |
| Databáze: | OpenAIRE |
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