Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9,Histological Changes and Renal Function in ExperimentalNephrotoxicity Induced by Gentamicin
| Autor: | Ruxandra Râjnoveanu, Adriana Elena Bulboacă, Vasile Rus, Gabriela Dogaru, Dana Gabriela Feștilă, Corneliu Angelo Bulboaca, Alexandra Ina Bulboaca, Alexandra Roman, Sorana D. Bolboacă, Alina Porfire, Cristina Nicula, Paul-Mihai Boarescu, Ioana Stanescu, Armand Râjnoveanu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry Renal function Pharmacology medicine.disease_cause Biochemistry Article Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine oxidative stress Liposomal Curcumin curcumin Gentamicin induced nephrotoxicity Molecular Biology Blood urea nitrogen Creatinine Kidney lcsh:RM1-950 Cell Biology Malondialdehyde 030104 developmental biology medicine.anatomical_structure lcsh:Therapeutics. Pharmacology chemistry 030220 oncology & carcinogenesis Oxidative stress |
| Zdroj: | Antioxidants, Vol 10, Iss 325, p 325 (2021) Antioxidants Volume 10 Issue 2 |
| ISSN: | 2076-3921 |
| Popis: | Background: Our study aimed to assess the efficiency of Curcumin nanoformulation (LCC) on experimental nephrotoxicity induced by Gentamicin in rats. Methods: Six groups of seven rats were used: C—(control group) received saline solution i.p. (i.p. = intraperitoneal), G—gentamicin (G, 80 mg/kg body weight (b.w.)), GCC1 and GCC2—with G and CC solution (single dose of 10 mg/kg b.w.-CC1, or 20 mg/kg b.w.-CC2), GLCC1 (10 mg/kg b.w.) and GLCC2 (20 mg/kg b.w.) with G and LCC administration. Oxidative stress parameters (NOx = nitric oxide, MDA = malondialdehyde, TOS = total oxidative stress), antioxidant parameters (CAT = catalase, TAC = total antioxidant capacity), matrix metalloproteinases (MMP-2 and MMP-9), and renal function parameters (creatinine, blood urea nitrogen, and urea) were measured. Kidneys histopathologic examination was made for each group. Results: Pretreatment with CC and LCC in both doses had significantly alleviating effects on assessed parameters (NOx, MDA, TOS, CAT, TAC, MMP-2, and -9) as compared with the untreated group (p < 0.006). Histopathological aspect and renal function were significantly improved in CC and LCC groups. Liposomal formulation (LCC) showed higher efficiency on all examined parameters compared to CC (p < 0.006). Conclusions: Our results demonstrated improving renal function and kidney cytoarchitecture, oxidative stress/antioxidant/balance, and MMPs plasma concentrations with better dose-related efficacity of LCC than CC. |
| Databáze: | OpenAIRE |
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