Clinical and pharmacokinetic interactions between oral fluconazole and intravenous ketamine and midazolam in dogs
| Autor: | David C. Rankin, Hyun Joo, Kara Berke, Ron Orchard, Butch KuKanich |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Sedation Midazolam Administration Oral Beagle Dogs Pharmacokinetics Heart rate Medicine Animals Ketamine Drug Interactions Fluconazole General Veterinary business.industry Pharmacodynamics Anesthesia Area Under Curve Administration Intravenous Female medicine.symptom business medicine.drug Half-Life |
| Zdroj: | Veterinary anaesthesia and analgesia. 46(6) |
| ISSN: | 1467-2995 |
| Popis: | Objective To evaluate drug interactions between fluconazole and the intravenous (IV) anesthetic induction agents, ketamine and midazolam. Study design Randomized parallel study. Animals A group of 12 adult healthy Beagle dogs. Methods Dogs were randomly allocated to two groups of six dogs. Dogs in group KM were administered IV ketamine (7 mg kg–1) and IV midazolam (0.25 mg kg–1), and dogs in group KMF were administered fluconazole (5 mg kg–1) orally 12 and 24 hours prior to ketamine–midazolam using the same doses as KM. Sedation scores (0–4) were assigned by investigators unaware of group assignment. Heart rate (HR) and times to sternal and standing were obtained and compared between groups for differences with p Results The times to sternal, mean 32.3 and 24.6 minutes, for groups KMF and KM, respectively, were not different between the groups. The time to standing, 73 and 36 minutes in groups KMF and KM, respectively, was significantly different (p = 0.002). The duration of elevated HR compared with baseline was longer in KMF (110 minutes) than in KM (25 minutes) (p Conclusions and clinical relevance A significant interaction between oral fluconazole and IV ketamine–midazolam occurred, but the effects appear minor in healthy dogs. Based on these data, a single dose of ketamine–midazolam is not contraindicated in dogs treated with fluconazole, but the duration of effects and pharmacokinetics are altered. |
| Databáze: | OpenAIRE |
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