Cooperation of the vestibular and cerebellar networks in anxiety disorders and depression

Autor: Anne Le Gall, Marie-Laure Machado, Stephane Besnard, Jan Cendelin, Jan Tuma, Pascal Hilber
Přispěvatelé: Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00 Plzen, Czech Republic, Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00 Plzen, Czech Republic., Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU)-Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Medicine Charles University and General Faculty Hospital in Prague, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2018
Předmět:
Cerebellum
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[SHS.PSY]Humanities and Social Sciences/Psychology
Affective neuroscience
03 medical and health sciences
0302 clinical medicine
Neural Pathways
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Animals
Humans
Biological Psychiatry
Pharmacology
Vestibular system
Depressive Disorder
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
[SCCO.NEUR]Cognitive science/Neuroscience
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Cognition
Vestibular Nuclei
Anticipation
Anxiety Disorders
030227 psychiatry
Motor coordination
Mood
medicine.anatomical_structure
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
[SCCO.PSYC]Cognitive science/Psychology
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Anxiety
medicine.symptom
Psychology
Neuroscience
Zdroj: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2019, 89, pp.310-321. ⟨10.1016/j.pnpbp.2018.10.004⟩
ISSN: 1878-4216
0278-5846
Popis: International audience; The discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas involved in fear and anxiety. Besides the brain areas that are classically associated with emotional reactivity , accumulating evidence indicates that both the vestibular and cerebellar systems are involved not only in motor coordination but also influence both cognition and emotional regulation in humans and animal models. The cerebellar and the vestibular systems show the reciprocal connection with a myriad of anxiety and fear brain areas. Perception anticipation and action are also major centers of interest in cognitive neurosciences. The cerebellum is crucial for the development of an internal model of action and the vestibular system is relevant for perception, gravity-related balance, navigation and motor decision-making. Furthermore, there are close relationships between these two systems. With regard to the cooperation between the vestibular and cerebellar systems for the elaboration and the coordination of emotional cognitive and visceral responses, we propose that altering the function of one of the systems could provoke internal model disturbances and, as a result, anxiety disorders followed potentially with depressive states.
Databáze: OpenAIRE
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