Changes in Vitamin A Levels and the Effect of Early Vitamin A Supplementation on Vitamin A Levels in Infants Throughout the First 6 Months of Life: A Prospective Cohort Study in Chongqing, China
| Autor: | Huan Liu, Ting Yang, Tingyu Li, Qi-Xiong Chen, Jie Chen, Lin-Chao Yu, Jingkun Miao |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
China Pediatrics medicine.medical_specialty Adolescent vitamin A supplements 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Humans Medicine Dietary survey Prospective Studies 030212 general & internal medicine Child Prospective cohort study Postnatal day Original Research Physical development business.industry Infant Newborn Public Health Environmental and Occupational Health medicine.disease infant Vitamin A deficiency chemistry Child Preschool Dietary Supplements Public Health Cutoff point vitamin A deficiency neonate Public aspects of medicine RA1-1270 business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Public Health, Vol 9 (2021) Frontiers in Public Health |
| ISSN: | 2296-2565 |
| DOI: | 10.3389/fpubh.2021.650823 |
| Popis: | Objectives: This study aimed to explore the changes in infant vitamin A (VA) status and the effect of early VA supplementation on VA level throughout the first 6 months of life.Methods: A prospective cohort study was conducted in Chongqing, China. A total of 1,016 healthy infants were enrolled at birth. Then, 930, 882, 854 and 822 healthy infants were followed up at postnatal day 7 and postnatal months 1, 3, and 6, respectively. Blood samples and dietary survey and physical development data were collected. Serum VA was measured by chromatography tandem-mass spectrometry and was classified according to the VA deficiency (VAD) criteria for older children aged 6–70 months (post hoc test, controlling for the effects of feeding pattern and sex.Results: Infant VA levels increased significantly from 0.499 ± 0.146 to 1.061 ± 0.414 μmol/L with age at 6 months, even without VA supplementation (P < 0.05). From birth to 6 months, the percentage of infants with a VA level P > 0.05). Infants with VA P < 0.05).Conclusions: A low VA level among neonates at birth may be a normal physiological state and may increase with age; thus, not all neonates may need early VA supplementation. More multicenter studies are needed to determine a new cutoff point for the diagnosis of neonatal VAD and the administration of nutritional intervention. |
| Databáze: | OpenAIRE |
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