Therapeutic Journey of Andrographis paniculata (Burm.f.) Nees from Natural to Synthetic and Nanoformulations
| Autor: | Sharuti Mehta, Rajesh K. Singh, Anil K. Sharma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Drug Biological Products Synthetic derivatives Traditional medicine Drug Compounding Andrographolide media_common.quotation_subject Active components General Medicine Biology Bitter taste biology.organism_classification Nanostructures chemistry.chemical_compound chemistry Target site Drug Discovery Animals Humans Andrographis Hepatoprotective Agent Andrographis paniculata media_common |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 21 |
| ISSN: | 1389-5575 |
| DOI: | 10.2174/1389557521666210315162354 |
| Popis: | Andrographis paniculata (Burm.f.) Nees (Acanthaceae) is a herbaceous plant and commonly called 'King of Bitters'. It has gained attraction as a potential hepatoprotective agent and a natural molecule with various biological activities viz. anticancer, immunomodulatory, anti-inflammatory, antibacterial, neuroprotective, and so on. The andrographolide is one of the main diterpenoids responsible for the drug's bitter taste and various therapeutic activities. The poor cellular permeability, solubility and short biological half-life of its pure components limit its distribution to the target tissue. To conquer this obstacle, various researchers worldwide have been working on designing the synthetic derivatives of its active components and nanoformulations to improve the drug's efficiency and selectivity to develop more active leads for biomedical applications. This article discussed the recent research on synthetic derivatives, including their possible therapeutic applications and structure-activity relationship (SAR). Additionally, this article also presents the essential information concerning the various nanoformulations developed to increase the delivery of pure compound/plant extract to the target site, thereby improving the drug's efficacy for multiple ailments. |
| Databáze: | OpenAIRE |
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