A Case with Petechiae due to Human Parvovirus B19
| Autor: | Yoshina Shimada, Kihei Terada, Yumiko Hiraga, Shoji Kawano, Yasuhiro Yagi, Naoki Kataoka |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Anemia Antibody titer General Medicine medicine.disease Thrombocytopenic purpura Virus Parvoviridae Infections medicine.anatomical_structure Antigen hemic and lymphatic diseases Truncus Parvovirus B19 Human Humans Medicine Female Platelet Bone marrow Child business Purpura |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 70:976-980 |
| ISSN: | 1884-569X 0387-5911 |
| Popis: | We reported a case of 10-year-old girl with petechiae mainly on the truncus, although who had more than 10 x 10(4)/microliter of platelets. Smears of her bone marrow demonstrated extreme reduction of erythroblasts with giant proerythroblast like cells, which does not consist with idiopathic thrombocytopenic purpura. Human parvovirus B19 (B19) DNA was detected in her serum and throat swab using PCR and significant alterations of B19 specific IgM and IgG antibody titers were demonstrated. The petechiae subsided on the 8th day after her admission. She had not shown anemia less than Hb 10 g/dl, but her reticulocytes counts had increased up to 3.5% on the 11th day after her admission. Smears of her bone marrow on the 17th day became normal with moderate erythroblasts. It is demonstrated that the cellular receptor of this virus is an antigen of the blood group P recently. P antigen is presented not only on erythrocytes and on erythroblasts but also on megakaryocytes and endotherial cells. Therefore, it is suggested that direct injury by B19 to endothelial cells could cause petechiae in this case. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|