Multiple effects of serum low-density lipoprotein on cultured human fibroblasts
| Autor: | L O Wosu, M J Spain, N Kalant |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
medicine.medical_specialty Basal rate Adolescent Cell Protein degradation Biology Glycosaminoglycan chemistry.chemical_compound Internal medicine Diabetes Mellitus medicine Humans Secretion Child Glycosaminoglycans Cell growth Cholesterol Age Factors General Medicine Fibroblasts Middle Aged Cell cycle Endocytosis Lipoproteins LDL Endocrinology medicine.anatomical_structure chemistry Protein Biosynthesis lipids (amino acids peptides and proteins) |
| Zdroj: | Canadian Journal of Biochemistry. 57:684-691 |
| ISSN: | 0008-4018 |
| DOI: | 10.1139/o79-086 |
| Popis: | The effects of serum low-density lipoproteins (LDL) were studied in cultures of human skin fibroblasts grown in medium supplemented with human serum deficient in lipoproteins and in platelet factor. The LDL led to a temporary increase in the rate of cell replication, to increases in the cell content of protein and cholesterol, to an increase in average cell size, and to an increased secretion of glycosaminoglycans. The increases in cholesterol and protein were proportional to the increase in cell size, suggesting that the additional protein and cholesterol were of a structural, rather than a storage, nature. The increase in cell protein during the first few days of exposure to LDL was due to a decrease in the rate of protein degradation. Ultrafiltration of the serum to remove substances of molecular weight |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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