Hepatic expression of ghrelin and adiponectin and their receptors in patients with nonalcoholic fatty liver disease
| Autor: | Martha H. Uribe, Nahum Méndez-Sánchez, Daniel Zamora-Valdés, Luisa Bermejo-Martínez, Guadalupe Ponciano-Rodríguez, Héctor Baptista-González, Misael Uribe, Roberto Medina-Santillán, Mucio Moreno-Portillo, Raúl Pichardo-Bahena |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy Gene Expression Specialties of internal medicine fatty acids digestive system chemistry.chemical_compound Internal medicine Nonalcoholic fatty liver disease Non alcoholic fatty liver disease Humans Medicine RNA Messenger Receptors Ghrelin adipokine hormone Hepatology Adiponectin medicine.diagnostic_test Triglyceride Interleukin-6 business.industry nutritional and metabolic diseases General Medicine Middle Aged medicine.disease digestive system diseases Fatty Liver Cross-Sectional Studies Endocrinology Liver RC581-951 chemistry ghrelin Liver biopsy Female Ghrelin Receptors Adiponectin Steatosis business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Annals of Hepatology, Vol 7, Iss 1, Pp 67-71 (2008) Scopus-Elsevier |
| ISSN: | 1665-2681 |
| DOI: | 10.1016/s1665-2681(19)31890-3 |
| Popis: | Background&aim: Adiponectin and ghrelin are hormones that participate in hepatic lipid metabolism, and their expression in liver tissue could have important implications for nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the hepatic expression of ghrelin, adiponectin, AdipoR, and IL-6 in patients with NAFLD and normal liver.Methods: We studied patients with clinical-pathological diagnosis of NAFLD or a normal liver. Patients were classified according to their diagnosis into three groups: normal liver, nonalcoholic hepatic steatosis, and nonalcoholic steatohepatitis (NASH). Adiponectin, AdipoR1, AdipoR2, IL-6, and ghrelin mRNA levels were assessed in biopsies by reverse transcriptasepolymerase chain reaction.Results: Of the 21 patients, three had a normal liver biopsy, 14 had nonalcoholic steatosis, and four had NASH. Patients with NAFLD exhibited significantly higher HOMA-IR and triglyceride concentration (both P < 0.05). There was a nonsignificant trend towards higher ghrelin expression in patients with NASH > nonalcoholic steatosis > normal liver. Patients with NASH had significantly higher mRNA adiponectin levels and lower IL-6 levels than did those with a normal liver (P < 0.05). AdipoR expression did not differ significantly between groups.Conclusion: Adiponectin overexpression was observed in patients with NASH. The role of hepatic ghrelin in NAFLD requires further research. |
| Databáze: | OpenAIRE |
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