Hypoglycemic activity of Eriobotrya japonica seeds in type 2 diabetic rats and mice
Autor: | Osamu Terai, Kazunari Tanaka, Nozomi Makino, Ikuo Ikeda, Shoko Nishizono, Shizuka Tamaru |
---|---|
Rok vydání: | 2008 |
Předmět: |
Blood Glucose
medicine.medical_specialty Ratón medicine.medical_treatment Blood sugar Mice Inbred Strains Type 2 diabetes Eriobotrya Applied Microbiology and Biotechnology Biochemistry Japonica Analytical Chemistry Mice Internal medicine Diabetes mellitus medicine Animals Hypoglycemic Agents Insulin Molecular Biology Glucose tolerance test Plants Medicinal medicine.diagnostic_test biology Chemistry Plant Extracts Organic Chemistry food and beverages Rats Inbred Strains General Medicine Glucose Tolerance Test medicine.disease biology.organism_classification Rats Endocrinology Diabetes Mellitus Type 2 Seeds Biotechnology Phytotherapy |
Zdroj: | Bioscience, biotechnology, and biochemistry. 72(3) |
ISSN: | 1347-6947 |
Popis: | The hypoglycemic effects of Eriobotrya japonica seeds were investigated in type 2 diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats and KK-A(y) mice. The rats and mice were fed on a diet containing 10% powdered Eriobotrya japonica seeds with the coat intact for 4 months. Although the blood glucose concentration in the OLETF rats fed on the control diet without Eriobotrya japonica seeds was increased with time, the concentration in the OLETF rats fed on the diet with Eriobotrya japonica seeds was consistently low throughout the experimental period and was comparable to the level in Long-Evans Tokushima Otsuka (LETO) rats which are normal non-diabetic rats. Serum insulin was significantly lower in the OLETF rats fed on the Eriobotrya japonica seed diet than in those fed on the control diet at the termination of the experimental period. Eriobotrya japonica seeds suppressed the increment of blood glucose for 4 months and also effectively improved the glucose tolerance in the KK-A(y) mice, these actions being mainly exerted by the ethanol extract of the seeds. These results suggest that Eriobotrya japonica seeds had a hypoglycemic property and the effect is attributable to the components extracted by ethanol. |
Databáze: | OpenAIRE |
Externí odkaz: |