Differences in systemic inflammation between cigarette and biomass smoke-induced COPD

Autor: José Luis López-Campos, Elena Arellano-Orden, Irene Martín-Robles, Pilar Sanjuán-López, Luis A. Pérez-de-Llano, Rafael Golpe, Carlos González-Juanatey
Přispěvatelé: [Golpe, Rafael] Univ Hosp Lucus Augusti, Med Res Serv, Lugo, Spain, [Martin-Robles, Irene] Univ Hosp Lucus Augusti, Med Res Serv, Lugo, Spain, [Sanjuan-Lopez, Pilar] Univ Hosp Lucus Augusti, Med Res Serv, Lugo, Spain, [Perez-de-Llano, Luis] Univ Hosp Lucus Augusti, Med Res Serv, Lugo, Spain, [Gonzalez-Juanatey, Carlos] Univ Hosp Lucus Augusti, Serv Cardiol, Lugo, Spain, [Lopez-Campos, Jose L.] Univ Hosp Virgen del Rocio, Med Surg Unit Resp Dis, Seville, Spain, [Lopez-Campos, Jose L.] Carlos III Hlth Inst, Ctr Biomed Res Resp Dis Network, Madrid, Spain, [Arellano-Orden, Elena] Carlos III Hlth Inst, Ctr Biomed Res Resp Dis Network, Madrid, Spain, Fundacion Ramon Dominguez
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Immunoglobulin E
Fibrinogen
Systemic inflammation
Gastroenterology
Comorbidities
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Forced Expiratory Volume
Smoke
Biomass
Lung
Obstructive pulmonary-disease
Original Research
COPD
Inhalation Exposure
medicine.diagnostic_test
biology
Smoking
Complete blood count
General Medicine
Middle Aged
Up-Regulation
Phenotypes
Erythrocyte sedimentation rate
Female
Profile
medicine.symptom
Inflammation Mediators
medicine.drug
Risk
medicine.medical_specialty
Inflammation
International Journal of Chronic Obstructive Pulmonary Disease
smoking
Exposure
03 medical and health sciences
Cardiovascular-disease
Internal medicine
medicine
Humans
Aged
business.industry
Protein
medicine.disease
cytokines
respiratory tract diseases
030104 developmental biology
Cross-Sectional Studies
030228 respiratory system
inflammation
biomass smoke
Exhaled nitric oxide
biology.protein
Tobacco-smoke
business
Biomarkers
Zdroj: International Journal of Chronic Obstructive Pulmonary Disease
Popis: Rafael Golpe,1 Irene Martín-Robles,1 Pilar Sanjuán-López,1 Luis Pérez-de-Llano,1 Carlos González-Juanatey,2 José L López-Campos,3,4 Elena Arellano-Orden4 1Respiratory Medicine Service, 2Cardiology Service, University Hospital Lucus Augusti, Lugo, 3Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocío, Sevilla, 4Center for Biomedical Research in Respiratory Diseases Network, Carlos III Health Institute, Madrid, Spain Background and objective: It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The aim of this study was to assess the inflammatory profile in B-COPD and T-COPD.Methods: A total of 20 subjects (15 men and five women) with T-COPD were matched one toone for sex, age and forced expiratory volume in 1s (FEV1) to 20 B-COPD patients. In all, 20 sex-matched healthy subjects with normal lung function without smoking history or biomass exposure were included as controls. The following biomarkers were measured: exhaled nitric oxide, serum IL-6, IL-8, IL-5, IL-13, periostin, surfactant protein-P, TNF-α, IgE, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Complete blood count was also obtained.Results: The age of the subjects was 70.2±7.9years and FEV1% was 56.2%±14.6%. Most inflammatory biomarkers were higher in both types of COPD than in healthy controls. IL-6, IL-8 and IL-5 were significantly higher in T-COPD than in B-COPD, without other significant differences.Conclusion: Both types of COPD are associated with high levels of systemic inflammation biomarkers. T-COPD patients have a higher systemic inflammatory status than the patients with B-COPD. Keywords: biomass smoke, COPD, cytokines, inflammation, smoking
Databáze: OpenAIRE
Externí odkaz: