A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila
| Autor: | Ella Preger-Ben Noon, Nicolás Frankel, Sebastian Kittelmann, Alistair P. McGregor |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
animal structures
Gene regulatory network Locus (genetics) Biology 03 medical and health sciences 0302 clinical medicine Pleiotropy Genetics Morphogenesis Animals Drosophila Proteins Gene Regulatory Networks Enhancer Gene 030304 developmental biology Regulation of gene expression 0303 health sciences Gene Expression Regulation Developmental Phenotype Biological Evolution Naked cuticle Evolutionary biology Larva Drosophila 030217 neurology & neurosurgery Developmental Biology Transcription Factors |
| Zdroj: | Current opinion in geneticsdevelopment. 69 |
| ISSN: | 1879-0380 |
| Popis: | The cuticle of insects is decorated with non-sensory hairs called trichomes. A few Drosophila species independently lost most of the dorso-lateral trichomes on first instar larvae. Genetic experiments revealed that this naked cuticle phenotype was caused by the evolution of enhancer function at the ovo/shavenbaby (ovo/svb) locus. Here we explore how this discovery catalyzed major new insights into morphological evolution in different developmental contexts, enhancer pleiotropy in gene regulation and the functionality and evolution of the Svb gene regulatory network (GRN). Taken together this highlights the importance of understanding the architecture and evolution of gene regulatory networks in detail and the great potential for further study of the Svb GRN. |
| Databáze: | OpenAIRE |
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