Characterization of 2,3,6,7,10,11-hexahydroxytriphenylene and its effects on cell viability in human cancer cell lines
| Autor: | Cristiane R. Zuconelli, Sheila M.B. Winnischofer, Karine P. Naidek, Ronny R. Ribeiro, Otavio Martins Cruz, Herbert Winnischofer |
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| Rok vydání: | 2016 |
| Předmět: |
Cell Survival
Apoptosis 02 engineering and technology Biology 010402 general chemistry Bioinformatics 01 natural sciences Biochemistry chemistry.chemical_compound Structure-Activity Relationship Annexin Glioma medicine Tumor Cells Cultured Cytotoxic T cell Humans Viability assay Cytotoxicity Lung cancer Molecular Biology Cell Proliferation Dose-Response Relationship Drug Cell Biology Phenanthrenes 021001 nanoscience & nanotechnology medicine.disease Molecular biology 0104 chemical sciences chemistry Cell culture Drug Screening Assays Antitumor 0210 nano-technology DNA |
| Zdroj: | Biochemistry and cell biology = Biochimie et biologie cellulaire. 94(2) |
| ISSN: | 1208-6002 |
| Popis: | We synthesized 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP), characterized it by electrochemistry, spectroelectrochemistry, and electron paramagnetic resonance techniques, and evaluated its cytotoxicity to human cancer cell lines. The results revealed that HHTP has accessible higher-oxidation states, especially the tris-semiquinone monoradical. This species is stable and is formed after being stored for months. HHTP exhibited cytotoxic effects on 5 human cancer cell lines, including glioma and lung cancer cells. The cytotoxic effect was evaluated based on the decrease in cell viability, increases in the percentage of cells with fragmented DNA, and elevated numbers of annexin V–PI-positive cells after HHTP treatment. |
| Databáze: | OpenAIRE |
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