Biologic modulators in allergic and autoinflammatory diseases
| Autor: | Stephen I. Wasserman, Lori Broderick, Arthur Kavanaugh, Louanne M. Tourangeau |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Hypersensitivity
Immediate Specific protein Lymphoma medicine.drug_class Recombinant Fusion Proteins medicine.medical_treatment Immunology Translational research Disease Monoclonal antibody Article Autoimmune Diseases Translational Research Biomedical Double-Blind Method Blocking antibody Respiratory Hypersensitivity medicine Humans Immunology and Allergy Molecular Targeted Therapy Receptors Cytokine Receptor Anaphylaxis Autoantibodies Randomized Controlled Trials as Topic Inflammation Clinical Trials as Topic Biological therapies business.industry Antibodies Monoclonal Immunoglobulin E Cytokine Cytokines business Immunosuppressive Agents |
| Zdroj: | Current Opinion in Allergy & Clinical Immunology. 11:355-360 |
| ISSN: | 1528-4050 |
| Popis: | PURPOSE OF REVIEW The advent of molecular techniques has resulted in the ability to tailor medications to specific protein targets. This review will emphasize several biological therapies, specifically directed toward cytokine receptors and inhibitors, and their role in the treatment of atopic and autoinflammatory diseases. RECENT FINDINGS Translational research and the identification of the molecular pathophysiology of diseases have led to more targeted treatment approaches. The biologic modulators encompassing monoclonal antibodies as cytokine inhibitors, receptor blocking antibodies, and new fusion receptors are now being applied to diseases beyond their original application. SUMMARY The expanded use of biological therapies has experienced success in the treatment of numerous disorders, especially in subsets of patients with disease that has been refractory to conventional therapies. |
| Databáze: | OpenAIRE |
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