Expanding the enantioselectivity of the gas-chromatographic chiral stationary phase chirasil-val-C11 by doping it with octakis(3-O-butanoyl-2,6-di-O-n-pentyl)-gamma-cyclodextrin
| Autor: | Anna Levkina, Volker Schurig, Pavel A. Levkin, Samuele Nazzi, Harri Czesla |
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| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Chromatography Cyclodextrin Enantioselective synthesis Filtration and Separation Polymer Analytical Chemistry Inclusion compound law.invention chemistry.chemical_compound chemistry law Organic chemistry Flame ionization detector Gas chromatography Enantiomer Derivatization |
| Zdroj: | Journal of separation science. 30(1) |
| ISSN: | 1615-9306 |
| Popis: | Combination of the enantioselective properties of the two versatile gas-chromatographic chiral stationary phases (CSPs) octakis(3-O-butanoyl-2,6-di-O-n-pentyl)-gamma-CD (Lipodex E) 1 and L-valine-diamide-based CSP Chirasil-Val-C11 2 has been realized by doping the chiral polymer 2 with the nonpolymeric selector 1. The resulting mixed-mode CSP Chirasil-Val(gamma-Dex) 3 was found to have a greatly improved enantioselectivity toward proline and aspartic acid (as N-trifluoroacetyl ethyl or methyl esters) in comparison to the single-mode CSP 2. The presence of the CD selector in 3 extended the scope of gas-chromatographic enantioseparations achievable on 2 to underivatized alcohols, terpenes, and other chiral compounds that are exclusively enantioseparated on 1. |
| Databáze: | OpenAIRE |
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