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Exosomes are bilayer lipid membrane nanoparticles that can contain DNA, mRNA, proteins, etc. Exosomes can be considered safe because they are produced endogenously. Today, utilizing exosomes as a cell-free procedure is considered to be approved in regenerative medicine. They are being used in dental regenerative medicine as well. In this review, we briefly describe exosomes, their characteristics, routes of isolation, and ways of administration. In addition, some therapeutic aspects of these extracellular vesicles, especially in dental degenerative lesions, are also discussed. Based on previous studies, exosome therapy is beneficial in dental regeneration. Exosomes can induce dental pulp regeneration and periodontal regeneration. For instance, they can promote angiogenesis and neurogenesis, or stimulate bone regeneration in the periodontal ligaments and alveolar bone, among many other therapeutic aspects.It seems that exosomes will play a significant role in future medicine. Although exosomes are approved as beneficial for therapeutic purposes, it seems there is still a long way to go before they are applied to human treatments. However, perhaps one day it will come to reality. |
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