The Effects of Mycophenolate on the Formation of Granulation Tissue Post-operatively in Canine Tracheal Stent Patients (2014–2020)
| Autor: | Martin Lesser, Kevin F. Barber, Catherine A. Loughin, Dominic J. Marino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
tracheal stent
040301 veterinary sciences Veterinary medicine Tracheal collapse Cefovecin Mycophenolate law.invention 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Randomized controlled trial law Prednisone SF600-1100 medicine Clinical significance granulation tissue immunomodulatory 030304 developmental biology Original Research mycophenolate 0303 health sciences General Veterinary business.industry Granulation tissue 04 agricultural and veterinary sciences medicine.anatomical_structure Hydrocodone chemistry Anesthesia canine tracheal collapse Veterinary Science business medicine.drug |
| Zdroj: | Frontiers in Veterinary Science, Vol 8 (2021) Frontiers in Veterinary Science |
| ISSN: | 2297-1769 |
| Popis: | Objectives: To determine if mycophenolate mofetil reduces the incidence and severity of granulation tissue in-growth in canine tracheal stent patients.Study design: Randomized clinical trial.Animals: 111 dogs from the hospital population.Methods: Client-owned dogs that received an endoluminal self-expanding tracheal stent for canine tracheal collapse between 2014 and 2020 were randomly assigned into one of two treatment groups. Control group medication protocol consisted of prednisone 0.5 mg/kg PO BID/SID/EOD × 30 days, hydrocodone 0.25 mg/kg PO TID × 30 days, and cefovecin 8 mg/kg SQ post-placement. Mycophenolate group medication protocol was identical to the control group medication protocol with the addition of mycophenolate mofetil 10 mg/kg PO BID × 30 days, SID for life. Recheck tracheoscopy was performed at 1, 3, and 6 months post-stent placement. Presence and severity of granulation tissue were determined by tracheoscopy and were recorded as a percentage of tracheal lumen obstruction by blinded evaluators (none present, 25–50%, and >50%).Results: At none of the three time points was there a statistically significant difference in grade between controls and those receiving mycophenolate (p = 0.467, p = 0.330, and p = 0.410).Conclusions and Clinical Significance: Our results suggest that mycophenolate can be safely given to these patients but do not support that its administration will reduce the incidence and severity of granulation tissue. Although a difference was observed in the severity of granulation tissue between the two groups, loss to follow-up may have influenced conclusions. A larger study would be warranted to further evaluate the effect of mycophenolate on the development of granulation tissue. |
| Databáze: | OpenAIRE |
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