The relationship between the expression of Ki-67 and the prognosis of osteosarcoma
| Autor: | Yingquan Luo, Wanchun Wang, Lifang Wen, Yanshan Zhu, Ming Zeng, Jian Zhou |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Datasets as Topic Bone Neoplasms Kaplan-Meier Estimate TCGA dataset Cochrane Library lcsh:RC254-282 Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Antigens Neoplasm Surgical oncology Internal medicine Genetics medicine Humans Neoplasm Metastasis Stage (cooking) Neoplasm Staging Osteosarcoma biology business.industry Sarcoma Odds ratio lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis medicine.disease Up-Regulation Gene Expression Regulation Neoplastic Meta-analysis Ki-67 Antigen 030104 developmental biology 030220 oncology & carcinogenesis Ki-67 biology.protein business Clinicopathological features Publication Bias Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1471-2407 |
| Popis: | Background A number of studies have linked positive Ki-67 expression with the prognosis of osteosarcoma (OS) patients. However, the results have been conflicting. To address this controversy, we conducted an analysis using a meta-analysis and a TCGA dataset to estimate the value of Ki-67 expression in the prognosis of OS. Methods A comprehensive search for relevant papers was conducted using NCBI PubMed, Embase, Springer, ISI Web of Knowledge, the Cochrane Library, and CNKI regardless of the publication year. The associations between Ki-67 expression and the clinical features and main prognostic outcomes of OS were measured. The TCGA dataset was also analyzed. The pooled odds ratio (OR) and its 95% confidential intervals (CIs) were utilized for statistical analysis. Results Overall, a total of 12 studies with 500 cases were included, and the results indicated that the expression of Ki-67 was significantly associated with Enneking stage (OR = 6.88, 95% CI: 2.92–16.22, p p p Conclusion The present study strongly suggests that positive Ki-67 expression was associated with Enneking stage, distant metastasis, and overall survival of OS, and it may be used as a potential biomarker to predict prognosis and guide clinical therapy for OS. |
| Databáze: | OpenAIRE |
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