Therapy-Related Acute Myelogenous Leukemia With an 11q23/MLL Translocation Following Adjuvant Cisplatin and Vinorelbine for Non–Small-Cell Lung Cancer
Autor: | Valentin G. Robu, Bryan A. Faller, Hossein Borghaei |
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Rok vydání: | 2009 |
Předmět: |
Male
Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Vinblastine Vinorelbine Translocation Genetic Myelogenous Carcinoma Non-Small-Cell Lung hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Idarubicin Lung cancer neoplasms Aged Cisplatin Chemotherapy business.industry Chromosomes Human Pair 11 Histone-Lysine N-Methyltransferase medicine.disease respiratory tract diseases Leukemia Myeloid Acute Leukemia Cytarabine business Myeloid-Lymphoid Leukemia Protein Follow-Up Studies medicine.drug |
Zdroj: | Clinical Lung Cancer. 10:438-440 |
ISSN: | 1525-7304 |
DOI: | 10.3816/clc.2009.n.082 |
Popis: | Cisplatin-based chemotherapy has become an accepted standard in the adjuvant treatment of Non–Small-cell lung cancer (NSCLC). We present a case of acute myelogenous leukemia with an 11q23/ MLL rearrangement diagnosed 1 year after the completion of 4 cycles of cisplatin and vinorelbine for resected NSCLC. To our knowledge, this is the first case of therapy-related acute myelogenous leukemia (t-AML) associated with this chemotherapy combination. The literature on t-AML with the 11q23/ MLL rearrangement is reviewed. |
Databáze: | OpenAIRE |
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