PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis
| Autor: | Ming-Dong Zhang, Helen C. Lai, Francois Lallemend, Roman Chrast, Igor Adameyko, Jan Senderek, Marina Dusl, Luca Bartesaghi, Philip Harrer, Paula Fontanet, Claudia Stendel, Charles Petitpré, Alexandre Pattyn, Haohao Wu, Filipa Bouçanova, Maria Eleni Kastriti, Jean-Jacques Médard, Finja Berger, Mark A. Landy, Yiqiao Wang, Patrik Ernfors, Rolf Stucka, Natalia Akkuratova, Saida Hadjab, Laura Croci, Simone Wanderoy, G. Giacomo Consalez |
|---|---|
| Přispěvatelé: | Bartesaghi, Luca, Wang, Yiqiao, Fontanet, Paula, Wanderoy, Simone, Berger, Finja, Wu, Haohao, Akkuratova, Natalia, Bouçanova, Filipa, Médard, Jean-Jacque, Petitpré, Charle, Landy, Mark A., Zhang, Ming-Dong, Harrer, Philip, Stendel, Claudia, Stucka, Rolf, Dusl, Marina, Eleni Kastriti, Maria, Croci, Laura, Lai, Helen C., Consalez, GIANGIACOMO GERMANO, Pattyn, Alexandre, Ernfors, Patrik, Senderek, Jan, Adameyko, Igor, Lallemend, Francoi, Hadjab, Saida, Chrast, Roman |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Nociception Lineage (genetic) Neurogenesis Nerve Tissue Proteins Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Cell Lineage Progenitor cell Transcription factor lcsh:QH301-705.5 Neurons Gene Expression Profiling Neural crest Nociceptors Immunohistochemistry 030104 developmental biology medicine.anatomical_structure nervous system lcsh:Biology (General) NEUROD1 ISL1 Female Neuron Carrier Proteins Neuroscience Chickens 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Cell Reports Cell Reports, Vol 26, Iss 13, Pp 3484-3492.e4 (2019) Cell reports |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2019.02.098 |
| Popis: | SUMMARY The sensation of pain is essential for the preservation of the functional integrity of the body. However, the key molecular regulators necessary for the initiation of the development of pain-sensing neurons have remained largely unknown. Here, we report that, in mice, inactivation of the transcriptional regulator PRDM12, which is essential for pain perception in humans, results in a complete absence of the nociceptive lineage, while proprioceptive and touch-sensitive neurons remain. Mechanistically, our data reveal that PRDM12 is required for initiation of neurogenesis and activation of a cascade of downstream pro-neuronal transcription factors, including NEUROD1, BRN3A, and ISL1, in the nociceptive lineage while it represses alternative fates other than nociceptors in progenitor cells. Our results thus demonstrate that PRDM12 is necessary for the generation of the entire lineage of pain-initiating neurons. Graphical Abstract In Brief The sensation of pain, temperature, and itch by neurons of the nociceptive lineage is essential for animal survival. Bartesaghi et al. report that the transcriptional regulator PRDM12 is indispensable in neural crest cells (NCCs) for the initiation of the sensory neuronal differentiation program that generates the entire nociceptive lineage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|