Evaluation of the efficacy and safety of direct oral anticoagulants in the treatment of portal vein thrombosis
| Autor: | Jay L. Martello, Haley N. Ilcewicz, Kara Piechowski |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Future studies Administration Oral Article 03 medical and health sciences 0302 clinical medicine medicine Humans Retrospective Studies Venous Thrombosis Hepatology Adult patients business.industry Portal Vein Gastroenterology Warfarin Anticoagulants Retrospective cohort study medicine.disease Portal vein thrombosis Surgery 030220 oncology & carcinogenesis Oral anticoagulant 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Eur J Gastroenterol Hepatol |
| ISSN: | 1473-5687 |
| Popis: | OBJECTIVE: The purpose of this study was to evaluate the efficacy and safety of direct oral anticoagulants vs. warfarin for portal vein thrombosis treatment. METHODS: This was a single-center, retrospective study. Adult patients initiated on a direct oral anticoagulant or warfarin for treatment of a new portal vein thrombosis were included. The primary failure outcome was the absolute difference in recurrent thromboembolic events 90 days following initiation of a direct oral anticoagulant vs. warfarin. The primary safety outcome was the absolute difference in bleeding events 90 days following initiation of a direct oral anticoagulant vs. warfarin. Descriptive statistics, Fisher’s exact, and Student’s t-tests were utilized as appropriate. RESULTS: Thirty-three patients were included. Thirteen (39.4%) patients received direct oral anticoagulants, and 20 (60.6%) received warfarin. None of the patients receiving direct oral anticoagulants experienced a primary failure event compared to four receiving warfarin (P < 0.001). None of the patients receiving direct oral anticoagulants experienced a primary safety event vs. one receiving warfarin (P < 0.001). CONCLUSION: Direct oral anticoagulants appear to be effective and safe in the treatment of portal vein thrombosis and in preventing recurrent thromboembolic events. Future studies with larger sample sizes are warranted to confirm direct oral anticoagulants’ efficacy in portal vein thrombosis. |
| Databáze: | OpenAIRE |
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