Impact of a history of metastases or synchronous metastases on survival in patients with locally recurrent rectal cancer
| Autor: | H.J.T. Rutten, D. van Zoggel, G.J.M. Creemers, E.L.K. Voogt, J. Nederend, J. S. Cnossen, G. van Lijnschoten, Jacobus W. A. Burger, Mark J. Roef, Miranda Kusters, G.A.P. Nieuwenhuijzen |
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| Přispěvatelé: | Surgery, CCA - Cancer Treatment and quality of life, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
metastasis‐ overall survival Individualized treatment 03 medical and health sciences 0302 clinical medicine Overall survival distant metastases Humans Medicine In patient Proportional Hazards Models Retrospective Studies Recurrent Rectal Cancer Curative intent free survival Rectal Neoplasms business.industry Hazard ratio locally recurrent rectal cancer Rectum Gastroenterology 030220 oncology & carcinogenesis Metastasis free survival Curative surgery 030211 gastroenterology & hepatology Radiology prognosis Neoplasm Recurrence Local business |
| Zdroj: | Colorectal Disease, 23(5), 1120-1131. Wiley-Blackwell Colorectal Disease, 23(5), 1120-1131. Wiley Voogt, E L K, van Zoggel, D M G I, Kusters, M, Nieuwenhuijzen, G A P, Cnossen, J S, Creemers, G J, van Lijnschoten, G, Nederend, J, Roef, M J, Burger, J W A & Rutten, H J T 2021, ' Impact of a history of metastases or synchronous metastases on survival in patients with locally recurrent rectal cancer ', Colorectal Disease, vol. 23, no. 5, pp. 1120-1131 . https://doi.org/10.1111/codi.15537 |
| ISSN: | 1462-8910 |
| Popis: | Aim: Patients with locally recurrent rectal cancer (LRRC) frequently present with either synchronous metastases or a history of metastases. This study was conducted to evaluate whether LRRC patients without metastases have a different oncological outcome compared to patients with a history of metastases treated with curative intent or patients with potentially curable synchronous metastases. Method: All consecutive LRRC patients who underwent intentionally curative surgery between 2005 and 2017 in a large tertiary hospital were retrospectively reviewed and categorized as having no metastases, a history of (curatively treated) metastases or synchronous metastases. Patients with unresectable distant metastases were excluded from the analysis. Results: Of the 349 patients who were analysed, 261 (75%) had no metastases, 42 (12%) had a history of metastases and 46 (13%) had synchronous metastases. The 3-year metastasis-free survival was 52%, 33% and 13% in patients without metastases, with a history of metastases, and with synchronous metastases, respectively (P |
| Databáze: | OpenAIRE |
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