Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression
| Autor: | Sandra P. Zoubovsky, Jay Schulkin, Louis J. Muglia, Michael T. Williams, Shivani Tumukuntala, Charles V. Vorhees, Sarah Hoseus |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Postpartum depression medicine.medical_specialty endocrine system Hypothalamo-Hypophyseal System Receptors Steroid Corticotropin-Releasing Hormone Physiology Receptor expression medicine.medical_treatment Hypothalamus Gene Expression Pituitary-Adrenal System Molecular neuroscience Article lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Mice 0302 clinical medicine Corticosterone Pregnancy Internal medicine medicine Animals Humans Circadian rhythm Receptor Maternal Behavior lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry medicine.disease Psychiatry and Mental health Steroid hormone 030104 developmental biology Endocrinology chemistry Female 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists Stress Psychological Paraventricular Hypothalamic Nucleus |
| Zdroj: | Translational Psychiatry Translational Psychiatry, Vol 10, Iss 1, Pp 1-13 (2020) |
| ISSN: | 2158-3188 |
| Popis: | Postpartum depression (PPD) affects up to 20% of mothers and has negative consequences for both mother and child. Although exposure to psychosocial stress during pregnancy and abnormalities in the hypothalamic pituitary adrenal (HPA) axis have been linked to PPD, molecular changes in the brain that contribute to this disease remain unknown. This study utilized a novel chronic psychosocial stress paradigm during pregnancy (CGS) to investigate the effects of psychosocial stress on maternal behavior, neuroendocrine function, and gene expression changes in molecular regulators of the HPA axis in the early postpartum period. Postpartum female mice exposed to CGS display abnormalities in maternal behavior, including fragmented and erratic maternal care patterns, and the emergence of depression and anxiety-like phenotypes. Dysregulation in postpartum HPA axis function, evidenced by blunted circadian peak and elevation of stress-induced corticosterone levels, was accompanied by increased CRH mRNA expression and a reduction in CRH receptor 1 in the paraventricular nucleus of the hypothalamus (PVN). We further observed decreased PVN expression of nuclear steroid hormone receptors associated with CRH transcription, suggesting these molecular changes could underlie abnormalities in postpartum HPA axis and behavior observed. Overall, our study demonstrates that psychosocial stress during pregnancy induces changes in neuroendocrine function and maternal behavior in the early postpartum period and introduces our CGS paradigm as a viable model that can be used to further dissect the molecular defects that lead to PPD. |
| Databáze: | OpenAIRE |
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