Prenatal organophosphate exposure can cause adverse birth outcomes to humans
| Autor: | Natrujee Wiwattanadittakul, Boonsita Suwannakul, Ratana Sapbamrer, Surat Hongsibsong |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Insecticides Health Toxicology and Mutagenesis Urinary system 010501 environmental sciences 01 natural sciences chemistry.chemical_compound Organophosphorus Compounds Pregnancy Environmental Chemistry Medicine Childbirth Humans Pesticides Adverse effect 0105 earth and related environmental sciences Fetus business.industry Obstetrics Organophosphate Infant Newborn Gestational age Infant Agriculture General Medicine Environmental Exposure medicine.disease Pollution Organophosphates chemistry Maternal Exposure Apgar score Female business |
| Zdroj: | Environmental science and pollution research international. 28(33) |
| ISSN: | 1614-7499 |
| Popis: | Organophosphate (OP) pesticides may accumulate in pregnant agricultural workers, resulting in adverse effects on the growth and development of the fetus and neonates. This study aims to evaluate a possible association between prenatal urinary OP metabolite levels among pregnant agricultural workers and birth outcomes of infants. This study also investigated the factors associated with urinary OP metabolites among pregnant agricultural workers. The spot urine samples were collected and analyzed for six OP metabolite levels. Birth outcomes data were abstracted from medical records. Multiple regression analysis found that gestational age at childbirth was negatively associated with diethylphosphate (DEP) levels (β = -0.073; 95% CI, -0.121, -0.024). Apgar score at 1 and 5 min after birth were negatively associated with diethyldithiophosphate (DEDTP) levels (β = -0.036; 95% CI, -0.069, -0.003; and β = -0.034, 95% CI, -0.057, -0.011, respectively). In addition, DEDTP levels were negatively associated with maternal age (β = -0.181; 95% CI, -0.339, -0.023), and dimethylphosphate (DMP) levels were positively associated with frequency of agricultural work during pregnancy (β = 31.554; 95% CI, 0.194, 62.914). Our results indicate that prenatal OP exposure can cause adverse birth outcomes in babies. Therefore, it is necessary to develop an effective strategy for reducing prenatal exposure to OP pesticides. |
| Databáze: | OpenAIRE |
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