Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome‐wide association study
| Autor: | Joseph K. Lim, Melinda L. Irwin, Antoinette M. Stroup, Hwai I. Yang, Shiori Suzuki, Brenda Y. Hernandez, Yoichiro Kamatani, Claire E. Thomas, Jian-Min Yuan, Chiea Chuen Khor, Atsushi Goto, Mindie H. Nguyen, Harvey A. Risch, Hongyu Zhao, Woon-Puay Koh, Zhanwei Wang, Chizu Tanikawa, Mei Hsuan Lee, Xin Wei Wang, Robert S. Brown, Karen Pawlish, Jill Koshiol, Maarit Tiirikainen, Lopa Mishra, Yi Shen, Herbert Yu, Kirti Shetty, Anuradha Budhu, Dean L. Mann, Koichi Matsuda, Yu Han Huang, Lingeng Lu, Xiaomei Ma, Maria O. Hernandez, Tamar H. Taddei, Linda Lou Wong, Maria A. Guarnera, Motoki Iwasaki, Marshonna Forgues |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Genetics
nonalcoholic fatty liver disease Hepatology SAMM50 business.industry Gastroenterology Genome-wide association study RC799-869 Original Articles Diseases of the digestive system. Gastroenterology medicine.disease digestive system diseases liver cancer Chromosome (genetic algorithm) Hepatocellular carcinoma medicine Genetic predisposition Original Article business PNPLA3 genome‐wide association study |
| Zdroj: | JGH Open: An Open Access Journal of Gastroenterology and Hepatology JGH Open, Vol 5, Iss 12, Pp 1363-1372 (2021) |
| ISSN: | 2397-9070 |
| Popis: | Background and Aim Chronic hepatitis C virus (HCV) infection, long‐term alcohol use, cigarette smoking, and obesity are the major risk factors for hepatocellular carcinoma (HCC) in the United States, but the disease risk varies substantially among individuals with these factors, suggesting host susceptibility to and gene–environment interactions in HCC. To address genetic susceptibility to HCC, we conducted a genome‐wide association study (GWAS). Methods Two case‐control studies on HCC were conducted in the United States. DNA samples were genotyped using the Illumian microarray chip with over 710 000 single nucleotide polymorphisms (SNPs). We compared these SNPs between 705 HCC cases and 1455 population controls for their associations with HCC and verified our findings in additional studies. Results In this GWAS, we found that two SNPs were associated with HCC at P Genome‐wide association study (GWAS) showed that five SNPs in 22q13.31, three in PNPLA3 (rs2281135, rs2896019, and 4823173) and two in SAMM50 (rs3761472 and rs3827385), were associated with HCC in the United States. |
| Databáze: | OpenAIRE |
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