Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight/obesity

Autor: Di Bonito, P., Pacifico, L., Chiesa, C., Valerio, G., Miraglia Del Giudice, E., Maffeis, C., Morandi, A., Invitti, C., Licenziati, M. R., Loche, S., Tornese, G., Franco, F., Manco, M., Baroni, M. G., Driul, D., Grandone, A., Incani, M., Pani, M. G., Tomat, Michela, Sanguigno, E., Gilardini, L., Pellegrin, M. C.
Přispěvatelé: Di Bonito, P., Pacifico, L., Chiesa, C., Valerio, G., Miraglia Del Giudice, E., Maffeis, C., Morandi, A., Invitti, C., Licenziati, M. R., Loche, S., Tornese, G., Franco, F., Manco, M., Baroni, M. G., Driul, D., Grandone, A., Incani, M., Pani, M. G., Tomat, Michela, Sanguigno, E., Gilardini, L., Pellegrin, M. C., Di Bonito, P, Pacifico, L, Chiesa, C, Valerio, G, Miraglia Del Giudice, E, Maffeis, C, Morandi, A, Invitti, C, Licenziati, M R, Loche, S, Tornese, G, Franco, F, Manco, M, Baroni, M G
Rok vydání: 2016
Předmět:
Blood Glucose
Male
endocrine system diseases
Endocrinology
Diabetes and Metabolism
prediabetes
Overweight
Impaired glucose tolerance
0302 clinical medicine
Endocrinology
impaired fasting glucose
Prevalence
Insulin
030212 general & internal medicine
Prediabetes
Child
Glucose tolerance test
medicine.diagnostic_test
Cardiometabolic risk factors
Impaired fasting glucose
Pediatric obesity
Fasting
Diabetes and Metabolism
Italy
Prediabete
Adolescent
Case-Control Studies
Female
Glucose Intolerance
Glucose Tolerance Test
Humans
Insulin Resistance
Obesity
Prediabetic State
medicine.symptom
Case-Control Studie
hormones
hormone substitutes
and hormone antagonists
Human
medicine.medical_specialty
pediatric obesity
030209 endocrinology & metabolism
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Cardiometabolic risk factor
business.industry
Case-control study
nutritional and metabolic diseases
medicine.disease
cardiometabolic risk factors
impaired glucose tolerance
business
Zdroj: Journal of endocrinological investigation (Online) 40 (2017): 409–416. doi:10.1007/s40618-016-0576-8
info:cnr-pdr/source/autori:Di Bonito P 1, Pacifico L 2, Chiesa C 3, Valerio G 4, Miraglia Del Giudice E 5, Maffeis C 6, Morandi A 6, Invitti C 7, Licenziati MR 8, Loche S 9, Tornese G 10, Franco F 11, Manco M 12, Baroni MG 13,14; "CARdiometabolic risk factors in overweight and obese children in ITALY" (CARITALY) Study Group./titolo:Impaired fasting glucose and impaired glucose tolerance in children and adolescents with overweight%2Fobesity./doi:10.1007%2Fs40618-016-0576-8/rivista:Journal of endocrinological investigation (Online)/anno:2017/pagina_da:409/pagina_a:416/intervallo_pagine:409–416/volume:40
ISSN: 1720-8386
DOI: 10.1007/s40618-016-0576-8
Popis: OBJECTIVE: To investigate in a large sample of overweight/obese (OW/OB) children and adolescents the prevalence of prediabetic phenotypes such as impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), and to assess their association with cardiometabolic risk (CMR) factors including hepatic steatosis (HS). METHODS: Population data were obtained from the CARdiometabolic risk factors in children and adolescents in ITALY study. Between 2003 and 2013, 3088 youths (972 children and 2116 adolescents) received oral glucose tolerance test (OGTT) and were included in the study. In 798 individuals, abdominal ultrasound for identification of HS was available. RESULTS: The prevalence of IFG (3.2 vs. 3.3%) and IGT (4.6 vs. 5.0%) was similar between children and adolescents. Children with isolated IGT had a 2-11 fold increased risk of high LDL-C, non-HDL-C, Tg/HDL-C ratio, and low insulin sensitivity, when compared to those with normal glucose tolerance (NGT). No significant association of IFG with any CMR factor was found in children. Among adolescents, IGT subjects, and to a lesser extent those with IFG, showed a worse CMR profile compared to NGT subgroup. In the overall sample, IGT phenotype showed a twofold increased risk of HS compared to NGT subgroup. CONCLUSIONS: Our study shows an unexpected similar prevalence of IFG and IGT between children and adolescents with overweight/obesity. The IGT phenotype was associated with a worse CMR profile in both children and adolescents. Phenotyping prediabetes conditions by OGTT should be done as part of prediction and prevention of cardiometabolic diseases in OW/OB youth since early childhood.
Databáze: OpenAIRE
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