Transition Zone Prostate-specific Antigen Density Could Better Guide the Rebiopsy Strategy in Men With Prostate Inflammation at Initial Biopsy
| Autor: | Erfan Amini, Hassan Jamshidian, Maziar Gooshe, Mohsen Ayati, Amir Arbab, Farhad Pishgar, Mohammad Reza Nowroozi |
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| Rok vydání: | 2015 |
| Předmět: |
Image-Guided Biopsy
Male medicine.medical_specialty Prostate biopsy Urology Prostatitis Risk Assessment Sensitivity and Specificity Statistics Nonparametric Prostate cancer Predictive Value of Tests Prostate Biopsy medicine Humans Registries Aged Retrospective Studies medicine.diagnostic_test business.industry Age Factors Prostatic Neoplasms Ultrasonography Doppler Middle Aged Prostate-Specific Antigen medicine.disease Immunohistochemistry Surgery Prostate-specific antigen medicine.anatomical_structure ROC Curve Predictive value of tests Chronic Disease Multivariate Analysis business |
| Zdroj: | Urology. 86:985-990 |
| ISSN: | 0090-4295 |
| Popis: | Objective To assess the role of transition zone prostate-specific antigen density (TZPSAD) in determining rebiopsy strategy in men with prostate inflammation at initial biopsy. Materials and Methods Analysis was performed on data derived from transrectal ultrasound–guided prostate biopsy registry containing 2461 men who underwent biopsy between March 2005 and January 2015. Eligible patients were divided into 2 groups based on the presence of chronic inflammation in prostate. Group 1 consisted of 920 patients with histopathologic evidence of chronic inflammation and group 2 consisted of 1287 patients with no evidence of inflammation. Receiver operating characteristic curve analysis was performed to evaluate the accuracy of PSA, PSA density (PSAD), and TZPSAD for detecting prostate cancer (PCa) in each group. Patients who underwent rebiopsy during the study period were further assessed to determine factors that may predict the presence of PCa on subsequent biopsies. Results In group 1 patients, at 90% sensitivity for detecting PCa, PSAD and TZPSAD showed 19.7% and 37.8% specificity at cutoff values of 0.10 and 0.27 ng/mL/mL respectively, whereas in group 2 patients, PSAD and TZPSAD revealed 29.8% and 31.4% specificity, respectively. Chronic inflammation at initial biopsy was associated with a significant decrease in the likelihood of cancer detection during rebiopsy (odds ratio, 0.42; 95% confidence interval, 0.18-0.99). TZPSAD was found to be capable of sparing 39.8% of unnecessary rebiopsies in group 1 patients, whereas it spared 20.5% of unnecessary rebiopsies in group 2 patients. Conclusion Applying TZPSAD is advantageous in determining rebiopsy strategy in patients with proven inflammation of prostate at initial biopsy. |
| Databáze: | OpenAIRE |
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