Incorporation of Nitroprusside on Silica Nanoparticles—A Strategy for Safer Use of This NO Donor in Therapy

Autor:	Iury A. Paz, Cláudia F. Santos, Valdevane Rocha Araújo, Luiz Gonzaga de França Lopes, Eduardo H.S. Sousa, Elisane Longhinotti, Nilberto R.F. Nascimento, Camila P. Aquino, Igor F. Vasconcelos, Pedro Martins da Silva Filho, T. S. Ribeiro
Rok vydání:	2019
Předmět:	Male Nitroprusside Cell Survival Surface Properties Guinea Pigs Pharmaceutical Science Nanoparticle Aorta Thoracic 02 engineering and technology Pulmonary Artery Nitric Oxide 030226 pharmacology & pharmacy No donors Silica nanoparticles 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine SAFER Chlorocebus aethiops Drug Discovery Animals Nitric Oxide Donors Rats Wistar Cytotoxicity Vero Cells Chemistry Silicon Dioxide 021001 nanoscience & nanotechnology Combinatorial chemistry Rats Drug Liberation Drug delivery Nanoparticles Molecular Medicine 0210 nano-technology Porosity
Zdroj:	Molecular Pharmaceutics. 16:2912-2921
ISSN:	1543-8392 1543-8384
Popis:	Silica-based nanoparticles have been developed as powerful platforms for drug delivery and might also prevent undesired side effects of drugs. Here, a fast method to synthesize positively charged mesoporous silica nanoparticles (ζ = 20 ± 0.5 mV, surface area = 678 m
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b410450e4b68d2e433ac6c5756f84e86 https://doi.org/10.1021/acs.molpharmaceut.9b00110 Zobrazit plný text záznamu