Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6‐lead mobile ECG device and a standard 12‐lead ECG
| Autor: | Randy Brown, Todd Rudo, Borje Darpo, Michael J. Ackerman, Robert Kleiman, Johan M Bos, Svetlana Chamoun, David E. Albert |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Supine position Heart Diseases Remote patient monitoring Posture Cardiomyopathy electrocardiogram QT interval Time QRS complex Electrocardiography QTc Physiology (medical) Internal medicine interval duration measurements Heart rate medicine Diseases of the circulatory (Cardiovascular) system Humans Prospective Studies Bland–Altman plot Bland–Altman remote monitoring clinical trials business.industry Hypertrophic cardiomyopathy General Medicine Original Articles medicine.disease virtual trials RC666-701 Cardiology Electrocardiography Ambulatory Original Article Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Annals of Noninvasive Electrocardiology Annals of Noninvasive Electrocardiology, Vol 26, Iss 6, Pp n/a-n/a (2021) |
| ISSN: | 1542-474X 1082-720X |
| Popis: | Background Interval duration measurements (IDMs) were compared between standard 12‐lead electrocardiograms (ECGs) and 6‐lead ECGs recorded with AliveCor's KardiaMobile 6L, a hand‐held mobile device designed for use by patients at home. Methods Electrocardiograms were recorded within, on average, 15 min from 705 patients in Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic. Interpretable 12‐lead and 6‐lead recordings were available for 685 out of 705 (97%) eligible patients. The most common diagnosis was congenital long QT syndrome (LQTS, 343/685 [50%]), followed by unaffected relatives and patients (146/685 [21%]), and patients with other genetic heart diseases, including hypertrophic cardiomyopathy (36 [5.2%]), arrhythmogenic cardiomyopathy (23 [3.4%]), and idiopathic ventricular fibrillation (14 [2.0%]). IDMs were performed by a central ECG laboratory using lead II with a semi‐automated technique. Results Despite differences in patient position (supine for 12‐lead ECGs and sitting for 6‐lead ECGs), mean IDMs were comparable, with mean values for the 12‐lead and 6‐lead ECGs for QTcF, heart rate, PR, and QRS differing by 2.6 ms, −5.5 beats per minute, 1.0 and 1.2 ms, respectively. Despite a modest difference in heart rate, intervals were close enough to allow a detection of clinically meaningful abnormalities. Conclusions The 6‐lead hand‐held device is potentially useful for a clinical follow‐up of remote patients, and for a safety follow‐up of patients participating in clinical trials who cannot visit the investigational site. This technology may extend the use of 12‐lead ECG recordings during the current COVID‐19 pandemic as remote patient monitoring becomes more common in virtual or hybrid‐design clinical studies. |
| Databáze: | OpenAIRE |
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