Autoimmune conditions are associated with perioperative thrombotic complications in liver transplant recipients : A UNOS database analysis
| Autor: | Patrick M. McQuillan, Zakiyah Kadry, Dmitri Bezinover, Thomas Riley, Khaled Iskandarani, Piotr K. Janicki, Vernon M. Chinchilli, Fuat H. Saner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Databases Factual medicine.medical_treatment Medizin Autoimmune hepatitis 030204 cardiovascular system & hematology Liver transplantation Autoimmune Diseases Primary sclerosing cholangitis End Stage Liver Disease 03 medical and health sciences Postoperative Complications 0302 clinical medicine Primary biliary cirrhosis Neoplasms Autoimmune and oncologic conditions medicine Humans Retrospective Studies Antithrombotic prophylaxis business.industry Incidence Thrombosis Odds ratio Perioperative Middle Aged medicine.disease Portal vein thrombosis United States Surgery Hepatic artery thrombosis Anesthesiology and Pain Medicine Preoperative Period Female 030211 gastroenterology & hepatology business Transjugular intrahepatic portosystemic shunt Research Article |
| Zdroj: | BMC Anesthesiology |
| Popis: | OA gold Background: End stage liver disease (ESLD) is associated with significant thrombotic complications. In this study, we attempted to determine if patients with ESLD, due to oncologic or autoimmune diseases, are susceptible to thrombosis to a greater extent than patients with ESLD due to other causes. Methods: In this retrospective study, we analyzed the UNOS database to determine the incidence of thrombotic complications in orthotopic liver transplant (OLT) recipients with autoimmune and oncologic conditions. Between 2000 and 2012, 65,646 OLTs were performed. We found 4,247 cases of preoperative portal vein thrombosis (PVT) and 1,233 cases of postoperative vascular thrombosis (VT) leading to graft failure. Results: Statistical evaluation demonstrated that patients with either hepatocellular carcinoma (HCC) or autoimmune hepatitis (AIC) had a higher incidence of PVT (p = 0.05 and 0.03 respectively). Patients with primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and AIC had a higher incidence of postoperative VT associated with graft failure (p |
| Databáze: | OpenAIRE |
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