Small intra-individual variability of the pre-ejection period justifies the use of pulse transit time as approximation of the vascular transit
| Autor: | Frank J P M Huygen, Frank Grüne, Minke C. Kortekaas, Marit H. N. van Velzen, Sjoerd P. Niehof, Robert Jan Stolker |
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| Přispěvatelé: | Anesthesiology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Epidemiology lcsh:Medicine Hands Blood Pressure 030204 cardiovascular system & hematology Vascular Medicine Standard deviation Diagnostic Radiology Stiffness Electrocardiography 0302 clinical medicine Heart Rate Risk Factors Ultrasound Imaging Medicine and Health Sciences Prospective Studies lcsh:Science Musculoskeletal System Biological Variation Individual Multidisciplinary medicine.diagnostic_test Feet Radiology and Imaging Heart Middle Aged Arms Bioassays and Physiological Analysis medicine.anatomical_structure Cardiovascular Diseases Echocardiography Aortic Valve Physical Sciences Cardiology Legs Female Anatomy Research Article Artery Adult medicine.medical_specialty Imaging Techniques Materials Science Material Properties Pulse Wave Analysis Research and Analysis Methods Young Adult 03 medical and health sciences Vascular Stiffness Diagnostic Medicine Internal medicine Photoplethysmogram medicine Humans Mechanical Properties Pulse wave Photoplethysmography Aged business.industry Electrophysiological Techniques lcsh:R Biology and Life Sciences Gold standard (test) Toes medicine.disease Blood pressure Body Limbs Medical Risk Factors Cardiovascular Anatomy Arterial stiffness lcsh:Q Cardiac Electrophysiology business 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE, Vol 13, Iss 10, p e0204105 (2018) PLoS ONE PLoS One (online), 13(10):e0204105. Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | Background Vascular transit time (VTT) is the propagation time of a pulse wave through an artery; it is a measure for arterial stiffness. Because reliable non-invasive VTT measurements are difficult, as an alternative we measure pulse transit time (PTT). PTT is defined as the time between the R-wave on electrocardiogram and arrival of the resulting pulse wave in a distal location measured with photoplethysmography (PPG). The time between electrical activation of the ventricles and the resulting pulse wave after opening of the aortic valve is called the pre-ejection period (PEP), a component of PTT. The aim of this study was to estimate the variability of PEP at rest, to establish how accurate PTT is as approximation of VTT. Methods PTT was measured and PEP was assessed with echocardiography (gold standard) in three groups of 20 volunteers: 1) a control group without cardiovascular disease aged 50 years, and 3) a group with cardiovascular risk factors, defined as arterial hypertension, dyslipidemia, kidney failure and diabetes mellitus. Results Per group, the mean PEP was: 1) 58.5 ± 13.0 ms, 2) 52.4 ± 11.9 ms, and 3) 57.6 ± 11.6 ms. However, per individual the standard deviation was much smaller, i.e. 1) 2.0–5.9 ms, 2) 2.8–5.1 ms, and 3) 1.6–12.0 ms, respectively. There was no significant difference in the mean PEP of the 3 groups (p = 0.236). Conclusion In conclusion, the intra-individual variability of PEP is small. A change in PTT in a person at rest is most probably the result of a change in VTT rather than of PEP. Thus, PTT at rest is an easy, non-invasive and accurate approximation of VTT for monitoring arterial stiffness. |
| Databáze: | OpenAIRE |
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