Cilia-mediated hedgehog signaling in Drosophila
| Autor: | Anujaianthi Kuzhandaivel, Liza Alkhori, Sebastian Schultz, Mattias Alenius |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Medicin och hälsovetenskap animal structures Sensory Receptor Cells Kinesins macromolecular substances Protein Serine-Threonine Kinases Medical and Health Sciences General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Cognitive disabilities Internal medicine medicine Animals Drosophila Proteins Humans Hedgehog Proteins Amino Acid Sequence Cilia Drosophila (subgenus) RNA Small Interfering lcsh:QH301-705.5 Hedgehog Developmental Malformations biology Cilium fungi biology.organism_classification Smoothened Receptor Hedgehog signaling pathway Cell biology Endocrinology lcsh:Biology (General) Drosophila RNA Interference Developmental biology Signal Transduction |
| Zdroj: | Cell Reports, Vol 7, Iss 3, Pp 672-680 (2014) |
| ISSN: | 2211-1247 |
| Popis: | Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during development, which has led to the assumption that cilia-mediated Hh signaling is restricted to vertebrates. Here, we identify and characterize a cilia-mediated Hh pathway in Drosophila olfactory sensory neurons. We demonstrate that several fundamental key aspects of the vertebrate cilia pathway, such as ciliary localization of Smoothened and the requirement of the intraflagellar transport system, are present in Drosophila. We show that Cos2 and Fused are required for the ciliary transport of Smoothened and that cilia mediate the expression of the Hh pathway target genes. Taken together, our data demonstrate that Hh signaling in Drosophila can be mediated by two pathways and that the ciliary Hh pathway is conserved from Drosophila to vertebrates. At the time for thesis presentation publication was in status: Manuscript |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|