Systemic inflammation with sarcopenia predicts survival in patients with gastric cancer

Autor: Yu-Ying Liu, Guo-Tian Ruan, Yi-Zhong Ge, Qin-Qin Li, Qi Zhang, Xi Zhang, Meng Tang, Meng-Meng Song, Xiao-Wei Zhang, Xiang-Rui Li, Kang-Ping Zhang, Ming Yang, Chun-Lei Hu, Tong Liu, Hai-Lun Xie, Xiao-Yue Liu, Shi-Qi Lin, Min Weng, Qing-Hua Yao, Zheng-Ping Wang, Ming-Hua Cong, Han-Ping Shi
Rok vydání: 2022
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 149:1249-1259
ISSN: 1432-1335
0171-5216
Popis: The levels of platelet-related inflammation indicators and sarcopenia have been reported to affect the survival of patients with cancer. To evaluate the prognostic influence of platelet count (PLT), platelet lymphocyte ratio (PLR), and systemic immune inflammation index (SII), and SII combined with sarcopenia on the survival of patients with gastric cancer (GC).A total of 1133 patients with GC (812 male and 321 female, average age: 59.43 years) were evaluated. Receiver-operating characteristic curves were used to determine the best cutoff values of PLT, PLR, and SII, and univariate and multivariate Cox risk regression models were used to evaluate whether SII is an independent predictor of overall survival (OS). The prognostic SS (SII-sarcopenia) was established based on SII and sarcopenia. Finally, a comprehensive analysis of the prognostic SS was performed.SII had the strongest prognostic effect. The SII and OS of patients with GC were in an inverted U-shape (adjusted HR = 1.07; 95% CI 0.97-1.19; adjusted P = 0.179). In patients with SII 1800, SII was negatively correlated with OS (adjusted HR = 0.57; 95% CI 0.29-1.12; adjusted P = 0.102), however, there is no statistical difference. Interestingly, a high SS was associated with a poorer prognosis. The higher the SS score was, the worse the OS (P 0.001).SII is an independent prognostic indicator of GC, and high SII is related to poor prognosis. A higher SS score had worse survival. Thus, the prognostic SS is a reliable predictor of OS in patients with GC.
Databáze: OpenAIRE
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