Differences in Glycemic Control in Diabetic and Non-diabetic Patients with Parenteral Nutrition Using a Basal plus Correction Insulin Regimen: An Observational, Retrospective Study

Autor:	Ramos, Analía, Rabasa, Fernanda, Mendoza, Lilian, Cardenete, Joana, Gill, Pedro, Morilla, Alba, Cardona, Daniel, Pérez Pérez, Antonio, Universitat Autònoma de Barcelona
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Non-diabetic patients Gastroenterology 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine medicine 030212 general & internal medicine Diabetic patients Glycemic business.industry Insulin Brief Report Retrospective cohort study medicine.disease Parenteral nutrition Basal (medicine) Hyperglycemia Observational study Complication business
Zdroj:	Diabetes Therapy Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
ISSN:	1869-6961 1869-6953
Popis:	Introduction: Hyperglycemia is a frequent complication of parenteral nutrition (PN) in patients both with and without diabetes mellitis (DM). The aim of this study was to evaluate the quality of glucose control achieved with basal plus-correction insulin in surgical patients with and without a history of DM receiving PN. Methods: Retrospective evaluation of a protocol applied during the period of January 2013-December 2015. The insulin dose was started at 0.4 and 0.3 IU/kg/day in patients with previous DM and without a history of DM, respectively, and the target blood glucose (BG) was < 180 mg/dl. Mean BG levels, insulin total daily dose (TDD) and hypoglycemic (< 70 mg/dl) events on different days of PN were also evaluated. Results: Forty-one patients with previous type 2 DM and 39 without DM were evaluated. Glycemic control in both groups was as follows: during the first 48 h (230.4 +/- 67 vs. 189.4 +/- 38 mg/dl, p = 0.002); at the midpoint (224.6 +/- 58 vs. 181.3 +/- 27 mg/dl, p = 0.003); 48 h before ending TPN (196.4 +/- 43 vs. 169.8 +/- 40 mg/dl, p = 0.004). Insulin TDD was 0.5 +/- 0.3 U/kg/day in patients with DM and 0.37 +/- 0.3 units/kg/day in those without DM (p < 0.05). A total of 18 patients experienced hypoglycemic events, without differences between the groups. Conclusion: A basal-correction insulin regimen is an alternative method for managing hyperglycemia in non-critically ill surgical patients on PN.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40a9e56b21279087a62e9af7ce5a801 http://europepmc.org/articles/PMC5984936 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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