Early Life Antibiotic Exposure and the Subsequent Risk of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis
| Autor: | Yuan-yue Zhou, Xue Zhang, Hai-ying Yu, Li-ya Pan, Hai-yin Jiang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Autism Spectrum Disorder behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine mental disorders Developmental and Educational Psychology medicine Attention deficit hyperactivity disorder Humans 0501 psychology and cognitive sciences Public health Siblings 05 social sciences Confounding Antibiotic exposure medicine.disease Confidence interval Anti-Bacterial Agents Autism spectrum disorder Attention Deficit Disorder with Hyperactivity Meta-analysis Autism Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Zdroj: | Journal of autism and developmental disorders. 52(5) |
| ISSN: | 1573-3432 |
| Popis: | This study was conducted to assess this association between early life antibiotic exposure and the risk of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in later life. The results showed that early life antibiotic exposure was associated with an increased risk of ASD (OR = 1.13, 95% confidence interval (CI): 1.07–1.21) or ADHD (OR = 1.18, 95% CI: 1.1–1.27). However, this association for ASD (OR = 1.04, 95% CI: 0.97–1.11) or ADHD (OR = 0.98, 95% CI: 0.94–1.02) disappeared when data from sibling-matched studies were pooled. The statistically significant association between early life antibiotic exposure and ASD or ADHD in later life can be partially explained by unmeasured genetic and familial confounding factors. |
| Databáze: | OpenAIRE |
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