Long non-coding RNAs in head and neck squamous cell carcinoma: Diagnostic biomarkers, targeted therapies, and prognostic roles
| Autor: | Lei Zhang, Abigail N. Rankine, Zi-Hao Zhang, Zi-Fei Wang, Wan-Xin Zheng, Xiang Meng, Hao Gu, Qiu-Yue Lou |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Biology Metastasis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Biomarkers Tumor Diagnostic biomarker Animals Humans Multiple tumors Pharmacology Advanced stage RNA Cancer medicine.disease Prognosis Head and neck squamous-cell carcinoma Gene Expression Regulation Neoplastic 030104 developmental biology chemistry Head and Neck Neoplasms Cancer research Carcinoma Squamous Cell RNA Long Noncoding 030217 neurology & neurosurgery DNA |
| Zdroj: | European journal of pharmacology. 902 |
| ISSN: | 1879-0712 |
| Popis: | At present, emerging evidences shows that non-coding RNAs (ncRNAs) play crucial roles for development of multiple tumors. Amongst these ncRNAs, long non-coding RNAs (lncRNAs) play prominent roles in physiological and pathological processes. LncRNAs are a type of transcript of more than 200 nucleotides, which are a significant obsession in various types of tumors and have extremely complex regulatory networks with DNA, RNA, and proteins in tumor cells, so that lncRNAs have attracted wide attention from researchers. LncRNAs are RNA transcripts larger than 200 nucleotides and have been shown to serve important regulatory roles in different types of cancer via interactions with DNA, RNA and proteins. Head and neck squamous cell carcinoma (HNSCC) are is one of the most malignant tumors with low survival rates in advanced stages. Recently, lncRNAs have been demonstrated to be involved in a wide range of biological processes, including proliferation, metastasis, and prognosis of HNSCC. Therefore, this review describes molecular mechanisms of up- or down-regulation of lncRNAs and expounds their functions in pathology and clinical practices in HNSCC. It also highlights their potential clinical applications as biomarkers for the diagnosis, prognosis, and treatment of HNSCC. However, studies on lncRNAs are still not comprehensive, and more investigations are needed in the future. |
| Databáze: | OpenAIRE |
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