Correlation of World Health Organization 2010 Classification for Gastroenteropancreatic Neuroendocrine Neoplasms with the Prognosis of Ovarian Neuroendocrine Neoplasms: Kansai Clinical Oncology Group-Protocol Review Committee/Intergroup Study
| Autor: | Takashi Ushiwaka, Mitsutake Yano, Hirokuni Takano, Takaya Shiozaki, Kazuto Tasaki, Masamitsu Kurakazu, Ayumi Shikama, Taisuke Mori, Kimihiko Ito, Michiko Nonaka, Atsushi Arakawa, Kentaro Kai, Yasushi Iida, Kaei Nasu, Takashi Motohashi, Hideki Tokunaga, Hiroyuki Morisawa, Etsuko Fujimoto, Satoshi Nakagawa, Yuko Imamura, Yuki Yamada, Takashi Yamada, Haruto Nishida, Norihiro Teramoto, Tomohiko Tsuruta, Tsutomu Daa, Harunobu Matsumoto |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Endocrinology Diabetes and Metabolism Disease World Health Organization Small-cell carcinoma Cellular and Molecular Neuroscience Endocrinology Japan Paraganglioma Internal medicine medicine Biomarkers Tumor Humans Stage (cooking) Pathological Aged Gastrointestinal Neoplasms Retrospective Studies Ovarian Neoplasms Performance status Endocrine and Autonomic Systems business.industry Proportional hazards model Middle Aged medicine.disease Prognosis Pancreatic Neoplasms Exact test Neuroendocrine Tumors Cross-Sectional Studies Practice Guidelines as Topic Female business |
| Zdroj: | Neuroendocrinology. 111(4) |
| ISSN: | 1423-0194 |
| Popis: | Background: In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for ovarian NENs (O-NENs) and correlates with prognosis. Methods: Sixty-eight patients diagnosed with carcinoid, small cell carcinoma (pulmonary type), paraganglioma, non-small/large cell neuroendocrine carcinoma (NEC), mixed NEC, or undifferentiated carcinomas at 20 institutions in Japan were included in this retrospective cross-sectional study. We identified O-NENs through central pathological review using a common slide set, followed by reclassification according to WHO 2010 guidelines for GEP-NENs. A proportional hazards model was used to assess the association of prognostic factors (age, stage, performance status, histology, and residual disease) with overall survival (OS) and progression-free survival (PFS). Results: Of the 68 enrolled patients, 48 were eligible for analysis. All carcinoids (n = 32) were reclassified as NET G1/G2, whereas 14 of 16 carcinomas were reclassified as NEC/mixed adeno-NEC (MANEC) (Fisher’s exact test; p < 0.01). The OS/PFS was 49.0/42.5 months and 6.5/3.9 months for NET G1/G2 and NEC/MANEC, respectively. Histology revealed that NEC/MANEC was associated with increased risk of death (HR = 48.0; 95% CI, 3.93–586; p < 0.01) and disease progression (HR = 51.6; 95% CI, 5.54–480; p < 0.01). Conclusion: Retrospective adaption of GEP-NEN classification to O-NENs is feasible and correlates well with the prognosis of O-NENs. This classification could be introduced for ovarian tumors. |
| Databáze: | OpenAIRE |
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