Intravenous tryptophan administration attenuates cortisol secretion induced by intracerebroventricular injection of noradrenaline
| Autor: | Y. Kobayashi, Ken-ichi Yayou, Fumihiro Ohtani, Madoka Sutoh, Etsuko Kasuya |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine Cortisol secretion endocrine system medicine.medical_specialty Hydrocortisone Intracerebroventricular injection Absorption (skin) Norepinephrine 03 medical and health sciences Internal medicine polycyclic compounds medicine Animals Secretion Injections Intraventricular Dose-Response Relationship Drug business.industry Tryptophan 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science Peripheral blood Disease Models Animal 030104 developmental biology Endocrinology Injections Intravenous Cattle General Agricultural and Biological Sciences business Stress Psychological hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Animal Science Journal. 87:266-270 |
| ISSN: | 1740-0929 1344-3941 |
| Popis: | This study was conducted to investigate the possibility of suppression of stress-induced cortisol (CORT) secretion by tryptophan (TRP) administration and to better understand its regulatory mechanisms by using a noradrenaline (NA) injection into the third ventricle (3V) as a stress model in cattle. A total of 25 Holstein steers with a cannula in the 3V were used. First, the increase in CORT secretion was observed following a NA injection into the 3V in a dose-dependent manner, verifying the appropriateness of this treatment as a stress model of CORT secretion (Experiment 1). The effect of prior-administration of TRP into peripheral blood with a dose that has been demonstrated to increase brain 5-hydroxytryptamine levels on the elevation of plasma CORT induced by NA or corticotropin-releasing hormone (CRH) was then examined (Experiment 2). The prior administration of TRP suppressed NA-induced, but not CRH-induced, CORT elevation. These results suggest that an increase in TRP absorption into peripheral blood could suppress the stress-induced CORT secretion in cattle via the attenuation of the stimulatory effect of NA on the hypothalamic CRH release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text