Radioiodine therapy in voluminous multinodular non-toxic goitre
| Autor: | Marc Bonnyns, Jean Verelst, Daniel Glinoer |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Goiter Endocrinology Diabetes and Metabolism Thyroid Gland chemistry.chemical_element Iodine Iodine Radioisotopes Endocrinology Internal medicine medicine Humans Euthyroid Substitution therapy Radionuclide Imaging Goitre size Aged Retrospective Studies Aged 80 and over business.industry Radioiodine therapy Radiotherapy Dosage General Medicine Multinodular non-toxic goitre Middle Aged medicine.disease Surgery chemistry Female Radioactive iodine therapy business Goiter Nodular |
| Zdroj: | Acta endocrinologica. 122(4) |
| ISSN: | 0001-5598 |
| Popis: | Large doses of radioiodione were administered since 1969 to 15 euthyroid patients with compressive voluminous goitres. A decrease in goitre size was observed in all patients (between 15 and 63%, average 39%). Maximal effect on goitre size was attained rapidly, partially already after less than one year and was almost maximal after 24 to 30 months. No significant local adverse reactions were observed; no patient required steroid administration. Hypothyroidism followed radioiodine administration in 30% of the patients after 2 years; after 8 years, all those who had survived were hypothyroid, requiring substitution therapy. In all patients there was a marked improvement in compression symptoms. The use of radioactive iodine therapy constitutes an alternative to surgery in selected patients with large compressive goitres in whom surgery is contraindicated because of age or other medical conditions. |
| Databáze: | OpenAIRE |
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