Successful Treatment of Severe Atopic Dermatitis with Calcitriol and Paricalcitol in an 8-Year Old Girl
| Autor: | George Mastorakos, Anastasios Papadimitriou, Dimitrios T Papadimitriou, Christina Bothou, Eleni Dermitzaki, Alexis Alexopoulos, Kleanthis Kleanthous |
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| Přispěvatelé: | Soliman, Ashraf |
| Předmět: |
Paricalcitol
medicine.medical_specialty Calcitriol Side effect Case Report 030209 endocrinology & metabolism 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Hypercalciuria ddc:610 business.industry lcsh:RJ1-570 lcsh:Pediatrics General Medicine Atopic dermatitis medicine.disease Dermatology chemistry Secondary hyperparathyroidism business Cholecalciferol medicine.drug Kidney disease |
| Zdroj: | Web of Science Case Reports in Pediatrics Case Reports in Pediatrics, Vol 2018 (2018) |
| Popis: | Atopic dermatitis (AD) is a chronic inflammatory disease affecting children and adolescence. The traditional therapeutic options for AD, including emollients topically and immune modulatory agents systemically focusing on reducing skin inflammation and restoring the function of the epidermal barrier, are proven ineffective in many cases. Several studies have linked vitamin D supplementation with either a decreased risk to develop AD or a clinical improvement of the symptoms of AD patients. In this report, we present a girl with severe AD who under adequate supplementation with cholecalciferol was treated with calcitriol and subsequently with paricalcitol. She had significant improvement—almost healing of her skin lesions within 2 months, a result sustained for more than 3 years now. Because of hypercalciuria as a side effect from calcitriol therapy, treatment was continued with paricalcitol, a vitamin D analogue used in secondary hyperparathyroidism in chronic kidney disease. Calcitriol therapy may be considered as a safe and efficacious treatment option for patients with severe AD, particularly for those with refractory AD, under monitoring for possible side effects. Treatment with paricalcitol resolves hypercalciuria, is safe, and should be further investigated as an alternative treatment of atopic dermatitis and possibly other diseases of autoimmune origin. |
| Databáze: | OpenAIRE |
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