Design and proof-of-concept evaluation of a touchless connector system for preventing peritoneal dialysis-associated peritonitis
| Autor: | Ryan C. Hunter, Ibrahim O. Yekinni, Arthur G. Erdman, Michelle N. Rheault, Tom Viker, Sarah Elfering, Aaron Tucker |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
food.ingredient biology business.industry Pseudomonas aeruginosa Peritoneal dialysis fluid medicine.medical_treatment Peritonitis General Medicine Contamination medicine.disease_cause biology.organism_classification medicine.disease Article Peritoneal dialysis Surgery food Staphylococcus epidermidis Medicine Agar It impact business |
| Zdroj: | BMJ Innov |
| Popis: | IntroductionIn this paper, we describe the design of a touchless peritoneal dialysis connector system and how we evaluated its potential for preventing peritoneal dialysis-associated peritonitis, in comparison to the standard of care. The unique feature of this system is an enclosure within which patients can connect and disconnect for therapy, protecting their peritoneal catheters from touch or aerosols. MethodsWe simulated a worst-case contamination scenario by spraying 40mL of a standardized inoculum [1x107 colony-forming units (CFU) per milliliter] of test organisms, Staphylococcus epidermidis ATCC1228 and Pseudomonas aeruginosa ATCC39327, while test participants made mock connections for therapy. We then compared the incidence of fluid path contamination by test organisms in the touchless connector system and the standard of care. 4 participants were recruited to perform a total of 56 tests, divided in a 1:1 ratio between both systems. Peritoneal dialysis fluid sample from each test was collected and maintained at body temperature (37{degrees} C) for 16 hours before being plated on Luria Bertani agar, Mannitol Salts Agar and Pseudomonas isolation agar for enumeration. ResultsNo contamination was observed in test samples from the touchless connector system, compared to 65%, 75% and 70% incidence contamination for the standard of care on Luria Bertani agar, Mannitol Salts Agar and Pseudomonas isolation agar respectively. ConclusionResults show that the touchless connector system can prevent fluid path contamination even in heavy bacterial exposures and may help reduce peritoneal dialysis-associated peritonitis risks from inadvertent contamination with further development. O_TEXTBOXSUMMARY BOXO_ST_ABSWhat are the new findings?C_ST_ABSWe describe the design and evaluation of a touchless peritoneal dialysis connector system showing reduced incidence of bacterial contamination in comparison to the standard of care. How might it impact on healthcare in the future?Integrating the touchless connector system into peritoneal dialysis systems may help reduce peritonitis risks in patients. C_TEXTBOX |
| Databáze: | OpenAIRE |
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