Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma
| Autor: | T. G. Tolstikova, N. A. Zhukova, O. R. Grek, D. E. Semenov, S. V. Pozdnyakova, I. V. Sorokina |
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| Rok vydání: | 2005 |
| Předmět: |
Alanine
Male Betulin Liver Neoplasms General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Lymphoma chemistry.chemical_compound Mice chemistry Biochemistry Liver Amide Liver structure medicine Mice Inbred CBA Betulonic acid Animals Lymphoma Large B-Cell Diffuse Oleanolic Acid Oleanolic acid Hyaline Neoplasm Transplantation |
| Zdroj: | Bulletin of experimental biology and medicine. 140(3) |
| ISSN: | 0007-4888 |
| Popis: | Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions. |
| Databáze: | OpenAIRE |
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