Effects of antibodies against octreotide in two patients with acromegaly
| Autor: | Hans Ørskov, A. G. Harris, Andreas Kaal, Stig Engkjær Christensent, Jargon Weeket |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Octreotide Antibodies Endocrinology Internal medicine Acromegaly medicine Humans Aged biology business.industry Specific igg Middle Aged medicine.disease Somatostatin Long acting Immunization Growth Hormone Immunoglobulin G biology.protein Plasma disappearance rate Antibody business Half-Life medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | Summary Two patients developed specific IgG antibodies against octreotide after 2–3 years’ treatment for acromegaly with this long acting somatostatln analogue. The presence of these antibodies reduced the plasma disappearance rate of total extractable octreotide by 60 and 80% respectively. When compared to that of non-Immune acromegalic patients, the plasma half-life of octreotide in these two patients was 300 and 450 vs 110 min in those with no detectable octreotide antibodies. The sole observed con-sequence of the immunization was a marked prolongation of the Interval of maximum GH Inhibition from a mean of 5 to 8 and 10 h in the two patients described after octreotide injection. |
| Databáze: | OpenAIRE |
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