Radiographic resolution of chronic rhinosinusitis without polyposis after 6 weeks vs 3 weeks of oral antibiotics
| Autor: | Christopher T. Melroy, Frederick A. Kuhn, Marc G. Dubin |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Prognostic variable Time Factors medicine.drug_class Chronic rhinosinusitis Radiography Immunology Antibiotics Administration Oral Nasal Polyps Immunopathology medicine Humans Immunology and Allergy Sinusitis Retrospective Studies Rhinitis business.industry Chronic sinusitis Clindamycin Middle Aged medicine.disease Anti-Bacterial Agents Surgery Chronic Disease Female Tomography X-Ray Computed business medicine.drug |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 98:32-35 |
| ISSN: | 1081-1206 |
| Popis: | Background Maximal medical therapy is poorly defined in chronic sinusitis treatment. Objective To objectively evaluate the radiographic response of chronic rhinosinusitis without polyposis after 3 and 6 weeks of oral antibiotics. Methods Thirty-five patients with confirmed chronic sinusitis without polyposis (disease apparent on initial computed tomography [CT] with appropriate symptom duration) were prescribed 6 weeks of antibiotics. When possible, culture-directed antibiotics were used; otherwise clindamycin was used empirically. A CT was performed after 3 and 6 weeks of therapy. CTs were then graded by the Lund-Mackay system. Demographic data were reviewed. Results Of the 35 patients, 16 underwent all 3 CT scans and completed all 6 weeks of antibiotics. Three patients completed only 3 weeks of antibiotics, and 16 did not undergo the interval 3-week CT. Six patients (38%) had statistically significant improvement in their CT scans between weeks 3 and 6. In this subset of patients who improved, 37% of their overall radiographic improvement occurred in the 3- to 6-week treatment interval. No prognostic variables predicted which patients would radiographically improve after 3 weeks of antibiotics. Conclusion Some patients achieve radiographic improvement and disease resolution after the completion of a 3-week course of antibiotics. Therefore, maximal medical therapy for chronic sinusitis may consist of longer than 3 weeks of therapy to ensure maximal benefit. |
| Databáze: | OpenAIRE |
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