Association of APOA1-75G/A and +83C/T polymorphic variation with acute coronary syndrome patients in Kashmir (India)
| Autor: | Ina A. Bhat, Iqbal Qasim, Arshad A. Pandith, Usma Manzoor, Irfan Ahmad Bhat, Iqra Niyaz, Aabid Koul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Acute coronary syndrome medicine.medical_specialty 030204 cardiovascular system & hematology 01 natural sciences Gastroenterology 03 medical and health sciences 0302 clinical medicine Kashmir Polymorphism (computer science) 010608 biotechnology Internal medicine Cardiovascular Disease Genotype Haplotype Medicine Diseases of the circulatory (Cardiovascular) system Allele Acute Coronary Syndrome Polymorphism Gene business.industry Wild type medicine.disease RC666-701 APOA1 Gene lipids (amino acids peptides and proteins) Original Article Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular and Thoracic Research Journal of Cardiovascular and Thoracic Research, Vol 13, Iss 2, Pp 109-115 (2021) |
| ISSN: | 2008-6830 2008-5117 |
| Popis: | Introduction: Acute coronary syndrome (ACS) comes under the ambit of cardiovascular disease.APOA-1 gene plays a vital role in lipid metabolism and has been observed to have plausible role in ACS. This cross sectional case-control study was conducted to evaluate association between APOA1-75G/A(rs1799837), +83C/T (rs5069) genotypes and risk for ACS. Methods: The current case-control study that included confirmed 90 ACS cases and 150 healthy controls were genotyped for APOA1-75 G/A and +83 C/T by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLF) method. Results: APOA1-75G/A distribution of genotypes/alleles among cases and controls was seen proportionally same with no association to ACS (P = 0.5). APOA1+83 C/T variants showed protective effect with ACS where variant TT genotype presented more in controls (12%) than cases (1.6%) (P = 0.004) and likewise variant ‘T’ allele was found more in controls than ACS cases (9.4% vs.28.5% respectively: P < 0.05). Further, significantly high difference of CT genotype was seen among cases and controls 15% vs. 33% respectively (P = 0.002). The overall distribution of different haplotypes showed a marked difference in GT when compared with GC between cases and controls (P = 0.0001). Conclusion: The study shows that TT genotype and variant T allele of APOA1 +83 C/T depicted a protective role with respect to ACS whereas APOA1-75G>A showed no relation. Haplotype GT was observed to significantly over-represent in controls with its protective effect in ACS as against wild type haplotype GC. |
| Databáze: | OpenAIRE |
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