Blood biocompatibility of surface-bound multi-walled carbon nanotubes
| Autor: | Yurii K. Gun'ko, Marek W. Radomski, Alan M. Gaffney, Terry C. Major, Giuliano Elia, Kieran Wynne, Amro Satti, Maria Jose Santos-Martinez, Gail M. Annich |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Platelets
Proteomics Materials science Biocompatibility Surface Properties Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Biocompatible Materials Bioengineering Nanotechnology Carbon nanotube law.invention Microscopy Electron Transmission law In vivo Cardiopulmonary bypass Animals Humans General Materials Science Platelet Platelet activation Polyvinyl Chloride Blood Coagulation Cardiopulmonary Bypass Nanotubes Carbon Extracorporeal circulation Thrombosis Platelet Activation Nanostructures Perfusion Nanomedicine Platelet-rich plasma Microscopy Electron Scanning Biophysics Molecular Medicine Calcium Rabbits |
| Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine. 11:39-46 |
| ISSN: | 1549-9634 |
| DOI: | 10.1016/j.nano.2014.07.005 |
| Popis: | Blood clots when it contacts foreign surfaces following platelet activation. This can be catastrophic in clinical settings involving extracorporeal circulation such as during heart-lung bypass where blood is circulated in polyvinyl chloride tubing. Studies have shown, however, that surface-bound carbon nanotubes may prevent platelet activation, the initiator of thrombosis. We studied the blood biocompatibility of polyvinyl chloride, surface-modified with multi-walled carbon nanotubes in vitro and in vivo. Our results show that surface-bound multi-walled carbon nanotubes cause platelet activation in vitro and devastating thrombosis in an in vivo animal model of extracorporeal circulation. The mechanism of the pro-thrombotic effect likely involves direct multi-walled carbon nanotube-platelet interaction with Ca(2+)-dependant platelet activation. These experiments provide evidence, for the first time, that modification of surfaces with nanomaterials modulates blood biocompatibility in extracorporeal circulation. |
| Databáze: | OpenAIRE |
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