Pathological Features and Prognosis of Lobular Carcinoma in Egyptian Breast Cancer Patients
| Autor: | Hatem A. Azim, Raafat Ragaie Abdel Malek, Hamdy A. Azim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Lobular carcinoma Breast Neoplasms Disease Gastroenterology Disease-Free Survival Breast cancer Internal medicine Tumor stage medicine Humans skin and connective tissue diseases Pathological Neoplasm Staging Retrospective Studies business.industry Carcinoma Ductal Breast Hazard ratio Histology General Medicine Middle Aged Prognosis medicine.disease Survival Rate body regions Carcinoma Lobular Invasive lobular carcinoma Egypt Female business Follow-Up Studies |
| Zdroj: | Women's Health. 10:511-518 |
| ISSN: | 1745-5065 |
| DOI: | 10.2217/whe.14.48 |
| Popis: | Aim: To illustrate the differences between invasive lobular and ductal carcinomas (ILCs and IDCs) in terms of baseline demographics, pathologic features and recurrence in Egyptian breast cancer patients. Patients & methods: Retrospective analysis of breast cancer patients diagnosed and treated between 2000 and 2008 was performed. Results: 176 (8.5%) and 1758 (85%) cases were diagnosed with ILC and IDC, respectively. Compared with IDC, ILC was less observed in patients under 35 years of age (3.4 vs 9.3%; p = 0.009), and was associated with more bilaterality (p = 0.001), advanced tumor stage (p = 0.027) and nodal involvement (p = 0.004). On the other hand, IDC was significantly associated with more luminal B-like phenotype (16.9 vs 8.1%; p < 0.001) and more HER2-enriched disease (11.5 vs 2.7%; p < 0.001). At a median follow-up time of 64 months, ILC histology was independently associated with better disease-free survival (hazard ratio: 0.58; 95% CI: 0.36-0.93; p = 0.023). Bone and peritoneal relapses were more common in ILC, while lung relapses were more common in IDC. Conclusion: ILC has distinct biologic and prognostic features that may warrant different therapeutic approaches. |
| Databáze: | OpenAIRE |
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