Defective response inhibition and collicular noradrenaline enrichment in mice with duplicated retinotopic map in the superior colliculus
| Autor: | Elise Savier, Vincent Lelievre, Yannick Goumon, Nicholas Bevins, Chantal Mathis, Daniel Clesse, Christian Kelche, Dominique Sage-Ciocca, Anaïs Gillet, Jean-Christophe Cassel, Adrien Lacaud, Jean-Bastien Bott, Frank W. Pfrieger, Alexis Laux-Biehlmann, Karin Geiger, Michael Reber |
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| Přispěvatelé: | Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Cellulaires et Intégratives (INCI), Plateforme d'hébergement et d'exploration fonctionnelle (Chronobiotron) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Superior Colliculi Histology genetic structures Neuroscience(all) Attention-deficit disorders Dopamine LIM-Homeodomain Proteins Visual Acuity Mice Transgenic Anxiety Motor Activity Mice Norepinephrine Memory Monoaminergic EphA signaling Animals Visual Pathways Gene Knock-In Techniques Receptor Superior colliculus Depth Perception General Neuroscience Receptor EphA3 Multisensory integration Transporter Retinotopy Circadian Rhythm Gene expression profiling Mice Inbred C57BL Inhibition Psychological Monoamine neurotransmitter Response inhibition Noradrenaline Original Article Anatomy Visual system Psychology Neuroscience Psychomotor Performance [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology Transcription Factors |
| Zdroj: | Brain Structure and Function Brain Structure and Function, Springer Verlag, 2014, 220 (3), pp.1573-1584. ⟨10.1007/s00429-014-0745-5⟩ Brain Structure & Function |
| ISSN: | 1863-2653 1863-2661 |
| DOI: | 10.1007/s00429-014-0745-5⟩ |
| Popis: | The superior colliculus is a hub for multisensory integration necessary for visuo-spatial orientation, control of gaze movements and attention. The multiple functions of the superior colliculus have prompted hypotheses about its involvement in neuropsychiatric conditions, but to date, this topic has not been addressed experimentally. We describe experiments on genetically modified mice, the Isl2-EphA3 knock-in line, that show a well-characterized duplication of the retino-collicular and cortico-collicular axonal projections leading to hyperstimulation of the superior colliculus. To explore the functional impact of collicular hyperstimulation, we compared the performance of homozygous knock-in, heterozygous knock-in and wild-type mice in several behavioral tasks requiring collicular activity. The light/dark box test and Go/No-Go conditioning task revealed that homozygous mutant mice exhibit defective response inhibition, a form of impulsivity. This defect was specific to attention as other tests showed no differences in visually driven behavior, motivation, visuo-spatial learning and sensorimotor abilities among the different groups of mice. Monoamine quantification and gene expression profiling demonstrated a specific enrichment of noradrenaline only in the superficial layers of the superior colliculus of Isl2-EphA3 knock-in mice, where the retinotopy is duplicated, whereas transcript levels of receptors, transporters and metabolic enzymes of the monoaminergic pathway were not affected. We demonstrate that the defect in response inhibition is a consequence of noradrenaline imbalance in the superficial layers of the superior colliculus caused by retinotopic map duplication. Our results suggest that structural abnormalities in the superior colliculus can cause defective response inhibition, a key feature of attention-deficit disorders. Electronic supplementary material The online version of this article (doi:10.1007/s00429-014-0745-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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