| Autor: |
Carolina Caro-Vegas, Catalina Ramirez, Justin Landis, Adaora A. Adimora, Howard Strickler, Audrey L. French, Igho Ofotokun, Margaret Fischl, Eric C. Seaberg, Chia-ching J. Wang, Amanda B. Spence, Dirk P. Dittmer |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
AIDS |
| Popis: |
OBJECTIVE: This study compared the mutation profile and tumor mutational burden (TMB) in women living with HIV (WLWH) diagnosed with lung adenocarcinoma (n=8) or breast ductal neoplasm (n=13) that were enrolled into the Women’s Interagency and HIV Study (WIHS). DESIGN: Previous studies tend to focus on single-institutions based on sample availability, while this study is based on a representative, multi-center cohort that represents the racial and ethnic composition of women with HIV in the United States METHODS: The study sequenced the complete human exome of n = 26 cancer samples from HIV+ women, using Ion torrent next generation sequencing. The study cohort was compared to a HIV- cohort obtained from the Genomic Data Commons Data Portal of the NCI. HIV+ and HIV- cohorts were compared using ion torrent next-generation sequencing. RESULTS: There were no differences in known cancer mutations between breast cancer and lung cancer that developed in WLWH and those that developed in HIV seronegative (HIV-) women; however, WLWH presented a significantly higher tumor mutational burden (TMB) in comparison to HIV- patients. 75% of lung cancers and 61% of breast cancers were defined as TMB-high (more than 10 mutation/mb of DNA). CONCLUSIONS: This study affirms the recommendation that WLWH be included in clinical trials of novel treatments for these cancers. While these data are preliminary, the high TMB in WLHV suggests, paradoxically, that this immune challenged population may benefit greatly from immune checkpoint inhibitor therapies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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