The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children
Autor: | Eun Lee, So-Yeon Lee, Soo-Jong Hong |
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Rok vydání: | 2019 |
Předmět: |
medicine.medical_specialty
Interstitial lung diseases Pulmonology Disinfectant Population Review Article Pediatrics behavioral disciplines and activities Pulmonary function testing 03 medical and health sciences 0302 clinical medicine Pulmonary fibrosis medicine In patient 030212 general & internal medicine Intensive care medicine education Child education.field_of_study Lung business.industry Mortality rate lcsh:RJ1-570 lcsh:Pediatrics respiratory system medicine.disease respiratory tract diseases body regions medicine.anatomical_structure 030228 respiratory system Respiratory failure Pediatrics Perinatology and Child Health business Humidifier disinfectants |
Zdroj: | Clinical and Experimental Pediatrics Clinical and Experimental Pediatrics, Vol 63, Iss 7, Pp 251-258 (2020) |
ISSN: | 2713-4148 |
Popis: | Exposure to environmental factors can cause interstitial lung diseases (ILDs); however, such types of ILDs are rare. From 2007 to 2011, an ILD epidemic occurred in South Korea owing to inhalational exposure to toxic chemicals in humidifier disinfectants (HDs). HD-associated ILDs (HD-ILDs) are characterized by rapidly progressing respiratory failure with pulmonary fibrosis and a high mortality rate of 43.8%−58.0%. Although 18.1%−31.1% of the general population used HDs, only a small proportion of HD users were diagnosed with HD-ILDs. This finding suggests that investigation of the pathophysiologies underlying HD-ILDs is needed in addition to the identification of susceptibility to HD-ILDs. Further, there have been several concerns regarding the diverse health effects of exposure to toxic chemicals in HDs, including those that have not been identified, and long-term prognoses in terms of pulmonary function and residual pulmonary lesions observed on follow-up chest images. In this review, we summarize the clinical features, pathologic findings, and changes in radiologic findings over time in patients with HD-ILDs and the results of previous experimental research on the mechanisms underlying the effects of toxic chemicals in HDs. Studies are currently underway to identify the pathophysiologies of HD-ILDs and possible health effects of exposure to HDs along with the development of targeted therapeutic strategies. The experience of identification of HD-ILDs has encouraged stricter control of safe chemicals in everyday life. |
Databáze: | OpenAIRE |
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